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. 2025 Apr 22;68(9):9623–9637. doi: 10.1021/acs.jmedchem.5c00396

Table 3. In Vitro Off-Target Profiles of Lead Compounds.

compound Ki ± 95% CI
  May1 (pM) HIV-1 Pr (μM) pepsin (μM) renin (μM) cathepsin D (nM) cathepsin E (nM)
9 400 ± 200 >500 7.6 ± 2.5 >100 64 ± 8 26 ± 2
25 180 ± 150 >500 1.9 ± 0.9 >500 37 ± 3 91 ± 10