Table 1. Click Reaction under Continuous Flow Conditions.
| entry | product | solvent | Rt (min) | isolated yield (%) |
|---|---|---|---|---|
| 1 | 3a | DME | 17 | 93 |
| 2 | 3b | DME | 25 | 68 |
| 3 | 3c | DME | 28 | 98 |
| 4 | 3d | DME | 27 | 75 |
| 5 | 3a | toluene + DME | 20 | 93 |
| 6 | 3b | toluene | 20 | 91 |
| 7 | 3c | toluene | 30 | 89 |
| 8 | 3d | toluene | 30 | 93 |
| entry | product | solvent | Rt (min) | isolated yield (%) |
|---|---|---|---|---|
| 1 | 3a | DME | 17 | 93 |
| 2 | 3b | DME | 25 | 68 |
| 3 | 3c | DME | 28 | 98 |
| 4 | 3d | DME | 27 | 75 |
| 5 | 3a | toluene + DME | 20 | 93 |
| 6 | 3b | toluene | 20 | 91 |
| 7 | 3c | toluene | 30 | 89 |
| 8 | 3d | toluene | 30 | 93 |