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. 2025 Apr 18;27(17):4423–4427. doi: 10.1021/acs.orglett.5c00453

Table 1. Click Reaction under Continuous Flow Conditions.

entry product solvent Rt (min) isolated yield (%)
1 3a DME 17 93
2 3b DME 25 68
3 3c DME 28 98
4 3d DME 27 75
5 3a toluene + DME 20 93
6 3b toluene 20 91
7 3c toluene 30 89
8 3d toluene 30 93