Table 2. Productivity and STY Calculated for the Click Reaction.

entry	3a–3d	solvent	Pa (mmol/h)	RFb	STYc (mmol h–1 mL–1)	RFd
1	3a	DME	1.8	40	1.08	77
2	3b	DME	1.31	37	7.83 × 10–1	70
3	3c	DME	1.92	51	1.14	96
4	3d	DME	0.67	18	1 × 10–1	34
5	3a	toluene + DME	2.24	50	1.34	95
6	3b	toluene	1.77	50	1.06	95
7	3c	toluene	1.72	48	1.03	93
8	3d	toluene	1.92	51	1.15	97

^aProductivity: moles of product (calculated from the isolated yield) divided by the collection time required to collect the product obtained by the reaction of 0.8 mmol of azido pyridine 1a–1d (limiting agent of the telescoped process).

^bRelative factor of productivity in flow vs batch (P_flow/P_batch).

^cSTY: moles of product in the reactor, divided by the residence time and reactor volume.

^dRelative factor of STY in flow vs batch (STY_flow/STY_batch).