Table 4. Productivity (mmol/h) and STY (mmol mL–1 h–1) for the Flow Process Using ASIA Syrris Premium.
| entry | R | Rt (min) | yielda (%) | Pb (mmol/h) | RFc | STYd (mmol h–1 mL–1) | RFe |
|---|---|---|---|---|---|---|---|
| 1 | 3b | 60 | 94 | 1.88 × 10–1 | 47 | 6.27 × 10–2 | 16 |
| 2 | 3b | 30 | 92 | 3.68 × 10–1 | 69 | 1.23 × 10–1 | 23 |
| 3 | 3d | 60 | 96 | 1.92 × 10–1 | 48 | 6.40 × 10–2 | 16 |
| 4 | 3d | 45 | 91 | 2.43 × 10–1 | 46 | 8.09 × 10–2 | 15 |
| 5 | 3c | 60 | 86 | 1.72 × 10–1 | 43 | 5.73 × 10–2 | 14 |
All of the yields are isolated.
Productivity: moles of product (calculated from the isolated yield) divided by the collection time required to collect the product obtained by the reaction of 0.2 mmol of triazoles 3b–3d (limiting agent of the telescoped process).
Relative factor of productivity in flow vs batch (Pflow/Pbatch).
STY: moles of product in the reactor, divided by the residence time and reactor volume.
Relative factor of STY in flow vs batch (STYflow/STYbatch).
