Table 3.

Risks of Overall Mortality in Patients with Liver Cirrhosis According to the Models

Model	Unadjusted HR (95% CI)	p-value	Adjusted HR* (95% CI)	p-value	Adjusted HR† (95% CI)	p-value	Adjusted HR‡ (95% CI)	p-value
Child-Pugh class
Class A	(Ref)		(Ref)		(Ref)		(Ref)
Class B	2.040 (1.758–2.368)	<0.001	2.160 (1.860–2.509)	<0.001	2.164 (1.864–2.514)	<0.001	2.133 (1.836–2.478)	<0.001
Class C	4.334 (3.580–5.247)	<0.001	4.974 (4.096–6.039)	<0.001	4.979 (4.101–6.046)	<0.001	4.841 (3.985–5.880)	<0.001
ALBI grade
Grade 1	(Ref)		(Ref)		(Ref)		(Ref)
Grade 2	2.125 (1.496–3.020)	<0.001	2.104 (1.481–2.989)	<0.001	2.100 (1.478–2.983)	<0.001	2.041 (1.436–2.901)	<0.001
Grade 3	4.144 (2.935–5.852)	<0.001	4.374 (3.096–6.179)	<0.001	4.370 (3.094–6.173)	<0.001	4.203 (2.974–5.940)	<0.001
MELD
<10	(Ref)		(Ref)		(Ref)		(Ref)
10 to <20	2.148 (1.806–2.554)	<0.001	2.251(1.892–2.677)	<0.001	2.249 (1.890–2.675)	<0.001	2.225 (1.870–2.647)	<0.001
≥20	4.449 (3.675–5.386)	<0.001	4.901(4.042–5.942)	<0.001	4.894 (4.035–5.934)	<0.001	4.859 (4.006–5.894)	<0.001
MELDNa
<10	(Ref)		(Ref)		(Ref)		(Ref)
10 to <20	2.008 (1.682–2.397)	<0.001	2.095 (1.754–2.502)	<0.001	2.094 (1.754–2.501)	<0.001	2.077 (1.739–2.481)	<0.001
≥20	4.064 (3.387–4.877)	<0.001	4.487 (3.733–5.392)	<0.001	4.483 (3.729–5.389)	<0.001	4.420 (3.676–5.315)	<0.001
MELD3.0
<10	(Ref)		(Ref)		(Ref)		(Ref)
10 to <20	2.149 (1.737–2.658)	<0.001	2.163 (1.749–2.676)	<0.001	2.191 (1.771–2.711)	<0.001	2.176 (1.758–2.693)	<0.001
≥20	4.560 (3.679–5.652)	<0.001	4.913 (3.961–6.094)	<0.001	4.984 (4.016–6.185)	<0.001	4.892 (3.941–6.072)	<0.001

HR, hazard ratio; CI, confidence interval; ALBI, albumin-bilirubin; MELD, Model for End-Stage Liver Disease; MELDNa, MELD sodium; MELD3.0, MELD 3.0.

*Adjusted for age; ^†Adjusted for age and sex; ^‡Adjusted for age, sex, and etiology of liver disease.