Table 3.
Univariable and Multivariable Cox Regression Analysis of OS for Patients with Intrahepatic Cholangiocarcinoma Involving the Hepatic Hilum
| Variable | OS before PSM | OS after PSM | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariable analysis | Multivariable analysis | Univariable analysis | Multivariable analysis | ||||||||
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||||
| Caudate lobectomy | 0.673 (0.505–0.898) | 0.007 | 0.711 (0.530–0.953) | 0.023 | 0.687 (0.485–0.972) | 0.033 | 0.697 (0.492–0.988) | 0.042 | |||
| Combined vesse1 resection | 1.093 (0.821–1.456) | 0.542 | 1.174 (0.824–1.671) | 0.374 | |||||||
| Gender male | 0.776 (0.486–1.241) | 0.290 | 1.013 (0.561–1.831) | 0.966 | |||||||
| Vascular invasion | 1.096 (0.826–1.454) | 0.524 | 1.171 (0.823–1.667) | 0.381 | |||||||
| Hypertension | 1.150 (0.805–1.644) | 0.442 | 1.277 (0.806–2.024) | 0.298 | |||||||
| Cardiovascular accident | 1.732 (0.712–4.212) | 0.226 | 2.973 (1.085–8.141) | 0.034 | 2.634 (0.939–5.218) | 0.059 | |||||
| Diabetes | 0.919 (0.471–1.793) | 0.804 | 0.939 (0.414–2.134) | 0.881 | |||||||
| COPD | 1.190 (0.587–2.415) | 0.630 | 1.698 (0.746–3.861) | 0.207 | |||||||
| Arrhythmia | 0.905 (0.401–2.039) | 0.809 | 0.520 (0.128–2.112) | 0.361 | |||||||
| Preoperative bile duct drainage | 1.346 (0.950–1.906) | 0.095 | 1.629 (1.055–2.515) | 0.028 | 1.591 (1.030–2.456) | 0.036 | |||||
| Poor differentiation | 1.515 (1.130–2.030) | 0.005 | 1.402 (1.221–1.603) | 0.018 | 1.594 (1.103–2.305) | 0.013 | 1.478 (1.076–1.898) | 0.021 | |||
| Tumor diameter | 1.201 (0.919–1.569) | 0.181 | 1.156 (0.835–1.601) | 0.382 | |||||||
| Invasion of the whole bile duct | 1.549 (1.128–2.128) | 0.007 | 1.190 (0.851–1.665) | 0.308 | 1.422 (0.969–2.087) | 0.072 | |||||
| Invasion of liver parenchyma | 1.494 (1.130–1.974) | 0.005 | 1.358 (1.024–1.802) | 0.034 | 1.901 (1.328–2.720) | 0.000 | 1.737 (1.211–2.493) | 0.004 | |||
| Peritoneal invasion of the liver | 0.937 (0.651–1.349) | 0.728 | 1.092 (0.704–1.692) | 0.695 | |||||||
| Nerve invasion | 1.117 (0.849–1.469) | 0.429 | 1.219 (0.862–1.724) | 0.264 | |||||||
| ASA classification | 0.808 (0.427–1.525) | 0.510 | 0.583 (0.264–1.286) | 0.181 | |||||||
| Intraoperative hemorrhage | 1.053 (0.928–1.196) | 0.424 | 1.067 (0.896–1.270) | 0.467 | |||||||
| Intraoperative transfusion | 1.236 (0.940–1.624) | 0.129 | 1.287 (0.911–1.818) | 0.153 | |||||||
| Operation time | 0.870 (0.632–1.197) | 0.391 | 0.777 (0.509–1.186) | 0.242 | |||||||
| Second surgery | 1.177 (0.694–1.996) | 0.546 | 1.290 (0.652–2.551) | 0.465 | |||||||
| Length of hospital stay | 1.119 (0.890–1.407) | 0.335 | 1.061 (0.795–1.416) | 0.687 | |||||||
| Postoperative hospital stay | 1.155 (0.942–1.415) | 0.166 | 1.092 (0.842–1.417) | 0.505 | |||||||
| ICU treatment time | 1.037 (0.898–1.198) | 0.618 | 1.087 (0.910–1.299) | 0.359 | |||||||
| Total postoperative infection | 1.358 (0.772–2.387) | 0.288 | 1.052 (0.513–2.159) | 0.889 | |||||||
| Pulmonary infection | 2.890 (1.698–4.919) | 0.000 | 2.804 (1.627–4.831) | 0.000 | 2.018 (0.983–4.145) | 0.056 | |||||
| Abdominal infection | 0.956 (0.645–1.416) | 0.821 | 0.840 (0.482–1.464) | 0.538 | |||||||
| Incisional infection | 2.037 (0.834–4.977) | 0.118 | 2.650 (0.829–8.474) | 0.100 | |||||||
| Sepsis | 3.489 (0.858–14.193) | 0.081 | NA | NA | NA | NA | |||||
| Liver abscess | 2.765 (0.385–19.857) | 0.312 | NA | NA | NA | NA | |||||
| Abdominal effusion | 0.893 (0.583–1.367) | 0.602 | 0.991 (0.614–1.601) | 0.972 | |||||||
| Pleura effusion | 1.201 (0.710–2.032) | 0.495 | 1.066 (0.541–2.100) | 0.854 | |||||||
| Bile leakage | 1.220 (0.866–1.719) | 0.256 | 0.832 (0.511–1.356) | 0.461 | |||||||
| Post operative hemorrhage | 1.032 (0.561–1.900) | 0.919 | 0.963 (0.424–2.190) | 0.928 | |||||||
| Biliary fistula | 1.165 (0.162–8.354) | 0.879 | 1.277 (0.177–9.219) | 0.809 | |||||||
| Gastrointestinal obstruction | 2.416 (0.765–7.628) | 0.133 | 2.665 (0.833–8.526) | 0.099 | |||||||
| Hepatic insufficiency | 1.443 (0.863–2.413) | 0.162 | 1.883 (0.914–3.881) | 0.086 | |||||||
| Pulmonary insufficiency | 3.136 (0.773–12.730) | 0.110 | NA | NA | NA | NA | |||||
| Renal insufficiency | 2.043 (0.651–6.409) | 0.221 | 1.267 (0.176–9.095) | 0.814 | |||||||
| Cardiac insufficiency | 0.440 (0.062–3.140) | 0.413 | 1.015 (0.142–7.284) | 0.988 | |||||||
| R0 resection | 0.618 (0.443–0.864) | 0.005 | 0.634 (0.450–0.894) | 0.009 | 0.818 (0.516–1.297) | 0.393 | |||||