Table 4.

Univariable and Multivariable Cox Regression Analysis of DFS for Patients with Intrahepatic Cholangiocarcinoma Involving the Hepatic Hilum

Variable	DFS before PSM						DFS after PSM
	Univariable analysis			Multivariable analysis			Univariable analysis			Multivariable analysis
	HR (95% CI)	p-value		HR (95% CI)	p-value		HR (95% CI)	p-value		HR (95% CI)	p-value
Caudate lobectomy	0.634 (0.482–0.835)	0.001		0.684 (0.515–0.909)	0.009		0.676 (0.486–0.939)	0.020		0.708 (0.508–0.986)	0.041
Combined vesse1 resection	1.020 (0.777–1.338)	0.887					0.765 (0.546–1.072)	0.120
Gender male	0.860 (0.552–1.341)	0.506					0.914 (0.522–1.598)	0.752
Vascular invasion	1.007 (0.770–1.317)	0.960					0.785 (0.560–1.100)	0.160
Hypertension	1.085 (0.774–1.523)	0.635					1.334 (0.872–2.041)	0.185
Cardiovascular accident	1.458 (0.601–3.539)	0.405					2.660 (0.979–7.229)	0.055
Diabetes	0.815 (0.432–1.537)	0.528					1.132 (0.555–2.311)	0.733
COPD	1.123 (0.554–2.273)	0.748					0.738 (0.302–1.803)	0.505
Arrhythmia	0.658 (0.271–1.597)	0.355					0.932 (0.231–3.770)	0.922
Preoperative bile duct drainage	1.363 (0.982–1.892)	0.064					1.618 (1.067–2.454)	0.023		1.517 (0.998–2.305)	0.051
Poor differentiation	1.313 (1.000–1.723)	0.051					1.436 (1.019–2.023)	0.039		1.329 (0.940–1.881)	0.108
Tumor diameter	1.166 (0.904–1.503)	0.238					0.924 (0.653–1.306)	0.654
Invasion of the whole bile duct	1.274 (0.951–1.707)	0.104					1.048 (0.740–1.485)	0.792
Invasion of liver parenchyma	1.454 (1.118–1.892)	0.005		1.356 (1.089–1.697)	0.042		1.076 (0.775–1.493)	0.662
Peritoneal invasion of the liver	0.965 (0.688–1.353)	0.835					0.914 (0.601–1.390)	0.674
Nerve invasion	1.132 (0.874–1.468)	0.347					0.961 (0.692–1.334)	0.812
ASA classification	0.727 (0.396–1.333)	0.302					1.228 (0.587–2.567)	0.586
Intraoperative hemorrhage	1.058 (0.936–1.195)	0.366					0.962 (0.806–1.147)	0.664
Intraoperative transfusion	1.111 (0.857–1.440)	0.425					1.211 (0.871–1.684)	0.254
Operation time	0.708 (0.525–0.955)	0.024					1.065 (0.692–1.640)	0.774
Second surgery	1.296 (0.801–2.097)	0.292					1.160 (0.627–2.147)	0.637
Length of hospital stay	1.082 (0.871–1.345)	0.477					0.899 (0.687–1.176)	0.437
Postoperative hospital stay	1.132 (0.933–1.374)	0.210					0.976 (0.760–1.252)	0.846
ICU treatment time	0.948 (0.824–1.091)	0.456					0.884 (0.739–1.057)	0.176
Total postoperative infection	1.644 (1.014–2.664)	0.044		1.305 (0.700–2.432)	0.402		1.354 (0.765–2.398)	0.298
Pulmonary infection	2.594 (1.555–4.329)	0.000		2.180 (1.255–3.788)	0.006		1.032 (0.604–1.762)	0.909
Abdominal infection	0.937 (0.647–1.355)	0.728					0.796 (0.253–2.506)	0.696
Incisional infection	2.331 (1.031–5.273)	0.042		1.807 (0.633–5.165)	0.269		2.037 (0.834–4.977)	0.118
Sepsis	3.779 (0.930–15.353)	0.063					NA			NA
Liver abscess	2.504 (0.349–17.968)	0.361					NA			NA
Abdominal effusion	1.026 (0.695–1.515)	0.897					1.167 (0.741–1.839)	0.504
Pleura effusion	1.233 (0.762–1.995)	0.394					1.008 (0.513–1.981)	0.981
Bile leakage	1.186 (0.858–1.640)	0.301					1.124 (0.714–1.771)	0.614
Post operative hemorrhage	1.238 (0.707–2.167)	0.455					1.079 (0.549–2.119)	0.825
Biliary fistula	2.204 (0.545–8.923)	0.268					1.193 (0.294–4.838)	0.804
Gastrointestinal obstruction	2.721 (1.003–7.381)	0.049		2.263 (0.787–6.507)	0.130		2.301 (0.848–6.243)	0.102
Hepatic insufficiency	1.110 (0.634–1.943)	0.716					1.627 (0.796–3.327)	0.182
Pulmonary insufficiency	3.837 (0.944–15.594)	0.060					NA			NA
Renal insufficiency	2.048 (0.654–6.417)	0.219					0.833 (0.116–5.965)	0.855
Cardiac insufficiency	0.337 (0.047–2.403)	0.278					1.396 (0.194–10.021)	0.740
R0 resection	0.609 (0.445–0.834)	0.002		0.754 (0.621–0.956)	0.018		1.251 (0.794–1.971)	0.334