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. 2025 May 13;21(5):e70157. doi: 10.1002/alz.70157

FIGURE 2.

FIGURE 2

Cross‐sectional sedentary time x APOE‐ε4 on neurodegeneration and cognition. Plots include outliers. Sedentary time interacted with APOE‐ε4 carrier status on (A) total gray matter (β = ‐86.9, p = 0.02), (B) parietal lobe (β = ‐23.9, p = 0.02), and (C) frontal lobe (β = ‐46.9, p = 0.02) volumes. Models remained significant when adjusting for MVPA. Sedentary behavior time x APOE‐ε4 carrier status interacted on (D) Boston Naming Test performance (β = ‐0.01, p = 0.01) and (E) Hooper Visual Organization Test performance (β = ‐0.01, p = 0.01). All plots include outliers. Models remained significant when adjusting for MVPA. APOE, apolipoprotein E; MVPA, moderate‐to‐vigorous physical activity.