Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1965 Aug;96(2):475–483. doi: 10.1042/bj0960475

Vitamin D3 and calcium absorption in the chick

E S Holdsworth 1
PMCID: PMC1207062  PMID: 4284435

Abstract

1. An attempt has been made to locate the site of action of vitamin D3 as it affects the translocation of calcium across the intestine. 2. Calcium appears to be pumped out of cells by a process dependent on energy from metabolism. 3. The effects of cold, inhibitors and vitamin D3 on the translocation of calcium by everted sacs of intestine were studied and compared with results obtained in vivo. 4. A model was proposed to explain the results which suggests that vitamin D3 inhibits a metabolically operated pump that returns calcium from the mucosal cell to the lumen. 5. Some observations on the effect of sodium lauryl sulphate on the translocation of calcium in vivo and in vitro are reported.

Full text

PDF
475

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COATES M. E., HOLDSWORTH E. S. Vitamin D3 and absorption of calcium in the chick. Br J Nutr. 1961;15:131–147. doi: 10.1079/bjn19610014. [DOI] [PubMed] [Google Scholar]
  2. DE LUCA H. F., GRAN F. C., STEENBOCK H., REISER S. Vitamin D and citrate oxidation by kidney mitochondria. J Biol Chem. 1957 Sep;228(1):469–474. [PubMed] [Google Scholar]
  3. DE LUCA H. F., GRAN F. C., STEENBOCK H. Vitamin D and citrate oxidation. J Biol Chem. 1957 Jan;224(1):201–208. [PubMed] [Google Scholar]
  4. DELUCA H. F., ENGSTROM G. W., RASMUSSEN H. The action of vitamin D and parathyroid hormone in vitro on calcium uptake and release by kidney mitochondria. Proc Natl Acad Sci U S A. 1962 Sep 15;48:1604–1609. doi: 10.1073/pnas.48.9.1604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. HARRISON H. E., HARRISON H. C. Studies with radiocalcium; the intestinal absorption of calcium. J Biol Chem. 1951 Jan;188(1):83–90. [PubMed] [Google Scholar]
  6. HARRISON H. E., HARRISON H. C. Transfer of Ca45 across intestinal wall in vitro in relation to action of vitamin D and cortisol. Am J Physiol. 1960 Aug;199:265–271. doi: 10.1152/ajplegacy.1960.199.2.265. [DOI] [PubMed] [Google Scholar]
  7. Harris L. J., Innes J. R. The mode of action of vitamin D: Studies on hypervitaminosis D. The influence of the calcium-phosphate intake. Biochem J. 1931;25(1):367–390.5. doi: 10.1042/bj0250367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MIGICOVSKY B. B. Influence of vitamin D on calcium resorption and accretion. Can J Biochem Physiol. 1957 Dec;35(12):1267–1275. [PubMed] [Google Scholar]
  9. MILLER D., CRANE R. K. A procedure for the isolation of the epithelial brush border membrane of hamster small intestine. Anal Biochem. 1961 Jun;2:284–286. doi: 10.1016/s0003-2697(61)80014-6. [DOI] [PubMed] [Google Scholar]
  10. Nicolaysen R. Studies upon the mode of action of vitamin D: The influence of vitamin D on the absorption of calcium and phosphorus in the rat. Biochem J. 1937 Jan;31(1):122–129. doi: 10.1042/bj0310122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Norman A. W., DeLuca H. F. Vitamin D and the incorporation of [1-14C]acetate into the organic acids of bone. Biochem J. 1964 Apr;91(1):124–130. doi: 10.1042/bj0910124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. RASMUSSEN H., WALDORF A., DZIEWIATKOWSKI D. D., DELUCA H. F. CALCIUM EXCHANGE IN ISOLATED INTESTINAL VILLI. Biochim Biophys Acta. 1963 Sep 24;75:250–256. doi: 10.1016/0006-3002(63)90603-6. [DOI] [PubMed] [Google Scholar]
  13. SALLIS J. D., HOLDSWORTH E. S. Calcium metabolism in relation to vitamin D and adrenal function in the chick. Am J Physiol. 1962 Sep;203:506–512. doi: 10.1152/ajplegacy.1962.203.3.506. [DOI] [PubMed] [Google Scholar]
  14. SCHACHTER D., ROSEN S. M. Active transport of Ca45 by the small intestine and its dependence on vitamin D. Am J Physiol. 1959 Feb;196(2):357–362. doi: 10.1152/ajplegacy.1959.196.2.357. [DOI] [PubMed] [Google Scholar]
  15. WASSERMAN R. H., COMAR C. L., SCHOOLEY J. C., LENGEMANN F. W. Interrelated effects of L-lysine and other dietary factors on the gastrointestinal absorption of calcium 45 in the rat and chick. J Nutr. 1957 Jul 10;62(3):367–376. doi: 10.1093/jn/62.3.367. [DOI] [PubMed] [Google Scholar]
  16. WASSERMAN R. H., KALLFELZ F. A. Vitamin D3 and unidirectional calcium fluxes across the rachitic chick duodenum. Am J Physiol. 1962 Aug;203:221–224. doi: 10.1152/ajplegacy.1962.203.2.221. [DOI] [PubMed] [Google Scholar]
  17. WASSERMAN R. H. LACTOSE-STIMULATED INTESTINAL ABSORPTION OF CALCIUM: A THEORY. Nature. 1964 Mar 7;201:997–999. doi: 10.1038/201997a0. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES