Table 5. NLRP3 inflammasome inhibitors, with their IC50 values in cells and disease models.
| Inhibitor name | IC50 value in cells | Disease model | References |
|---|---|---|---|
| MCC950 | ∼7.5 nM (BMDMs) | Sepsis, gout, MS, T2D, atherosclerosis | 45 |
| Oridonin | ∼2.1 μM (THP-1) | Rheumatoid arthritis, sepsis | 107 |
| CY-09 | ∼6 μM (THP-1) | Gout, T2D, atherosclerosis | 61 |
| INF39 | ∼15 μM (THP-1) | Sepsis, peritonitis | 43 |
| OLT1177 | ∼0.9 μM (THP-1) | Osteoarthritis, gout | 108 |
| BAY 11-7082 | ∼10 μM (THP-1) | ALI, sepsis | 109 |
| Ac-YVAD-CMK | ∼1.3 μM (BMDMs) | Gout, peritonitis | 110 |
| Glyburide | ∼20 μM (THP-1) | Type 2 diabetes, atherosclerosis | 111 |
| VX-765 | ∼0.5 μM (THP-1) | Epilepsy, inflammatory diseases | 112 |