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. 2025 Apr 29;14(9):647. doi: 10.3390/cells14090647

Figure 1.

Figure 1

CRMP2 is hyperphosphorylated at Thr 509/514 and Ser 522, but total CRMP2 is unchanged in lysates of brain cortices of 4-month-old APP-SAA KI mice (AD) compared to brain cortices lysates from B6J hAbeta mice (Control, Ctrl). (S)-LCM decreased CRMP2 phosphorylation. In (A), lanes 1–3, Ctrl mice; lanes 4–6, AD mice treated with a vehicle; lanes 7–9, AD mice treated with (S)-LCM. (S)-LCM (10 mg/kg body weight) and a vehicle (Veh, 10 μL DMSO in 0.2 mL saline) were delivered by oral gavage for 7 days prior to analysis. In (B–D), statistical summaries based on densitometry data. Data are mean ± SD. N = 3 biological replicates. ** p < 0.01, *** p < 0.001.