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. 2025 Apr 29;14(9):647. doi: 10.3390/cells14090647

Figure 2.

Figure 2

CRMP2 is hyperphosphorylated at Tyr 32, Thr 509/514, Ser 522, and Thr 555 in cultured cortical neurons from APP-SAA KI mice (AD) compared to neurons from B6J hAbeta mice (Control, Ctrl). (S)-LCM prevented CRMP2 hyperphosphorylation at Thr 509/514 and Ser 522, but not at Tyr 32 and Thr 555. Cortical neurons were isolated from P1 AD and Ctrl mice of both sexes and cultured for 12–14 days in vitro (12–14 DIV). In (A), representative immunoblots. In (B–E), statistical summaries based on densitometry data. Where indicated, neurons were treated with either 10 µM (S)-LCM or a vehicle (Veh, 0.01% DMSO) for the last 7 days prior to analysis. GAPDH is a loading control. Data are mean ± SD, N = 4 experiments with cells from different platings. *** p < 0.001.