Table 3.

Diagnostic accuracy of plasma calprotectin and CRP for diagnosing remission in IBD patients

	UC (n = 99)			CD (n = 209)
	plasma calprotectin, EliATM (automated)	plasma calprotectin, CalprestTM (manual)	hs-CRP	plasma calprotectin, EliATM (automated)	plasma calprotectin, CalprestTM (manual)	hs-CRP
AUROCa	0.999b	0.986b	0.960	0.675c	0.662c	0.716
SE	0.001	0.01	0.02	0.05	0.05	0.05
95% CI	0.962–1.000	0.939–0.999	0.900–0.989	0.607–0.738	0.594–0.726	0.649–0.776
Optimal threshold	≤10.5	≤8.1	≤5.9	≤10.2	≤13.3	≤11.8
Sensitivity	98.63	87.67	90.41	48.04	67.6	62.01
95% CI	92.6–100.0	77.9–94.2	81.2–96.1	40.5–55.6	60.2–74.4	54.5–69.1
Specificity	100	100	96.15	83.33	63.33	76.67
95% CI	86.8–100.0	86.8–100.0	80.4–99.9	65.3–94.4	43.9–80.1	57.7–90.1
PPV	100	100	98.5	94.5	91.7	94.1
95% CI	95.0–100.0	94.4–100.0	92.0–100.0	87.6–98.2	85.6–95.8	88.2–97.6
NPV	96.3	74.3	78.1	21.2	24.7	25.3
95% CI	81.0–99.9	56.7–87.5	60.0–90.7	14.2–29.7	15.6–35.8	16.7–35.5
p valuea	<0.0001	<0.0001	<0.0001	0.0003	0.001	<0.0001

CRP, C-reactive protein; 95% CI, 95% confidence interval; PPV, positive predictive value; NPV, negative predictive value; SE, standard error.

^aDiagnostic accuracy calculated via ROC analysis according to DeLong et al. [17].

^bComparison of AUROC values for calprotectin accuracy between the two assays (EliA™ vs. Calprest™, p = 0.10).

^cComparison of the accuracy of the AUROC values for calprotectin between the two assays (EliA™ vs. Calprest™, p = 0.3).