Figure 3.

Roles of NF-κB signaling intermediates in T cell differentiation. This cartoon shows the phases of CD4 and CD8 T cell differentiation in the thymus (A, B) and the periphery (C-E) highlighting the roles of different components of the NF-κB signaling network. DN, double negative thymocyte. DP, double positive thymocyte. SP, single positive thymocyte. tTreg refers to thymic T reg while pTreg refers to peripheral Treg. Tfh is follicular helper CD4 T cell, Th is a CD4 T helper cell. CD8EFF is an effector CD8 T cell while CD8MEM is a memory CD8 T cell. TCM is central memory T cell. TRM is tissue resident memory T cell. This figure has been created with BioRender.com.