Table 4.
Multivariable-adjusted SHRs (95% CIs) for CAC burden with HF mortality stratified by ASCVD and PREVENT risk groups.
| CAC Score Group | N | Model 1 SHR (95% CI)A | p | Model 2 SHR (95% CI)B | p2 |
|---|---|---|---|---|---|
| ASCVD Low/Borderline Risk (PCE) | 36 | ||||
| 0 | Ref | Ref | Ref | Ref | |
| 1 to 99 | 3.31 (1.40 – 7.82) | 0.006 | 3.14 (1.32 – 7.49) | 0.010 | |
| 100 to 399 | 3.57 (1.12 – 11.37) | 0.031 | 3.35 (1.02 – 10.96) | 0.046 | |
| ≥400 | 20.97 (7.15 – 61.44) | <0.001 | 18.69 (6.36 – 54.95) | <0.001 | |
| Log (CAC+1) | 1.43 (1.21 – 1.69) | <0.001 | 1.41 (1.20 – 1.67) | <0.001 | |
| ASCVD Intermediate Risk (PCE) | 76 | ||||
| 0 | Ref | Ref | Ref | Ref | |
| 1 to 99 | 3.56 (1.03 – 12.34) | 0.045 | 3.74 (1.08 – 12.95) | 0.037 | |
| 100 to 399 | 8.17 (2.44 – 27.37) | 0.001 | 8.46 (2.54 – 8.20) | 0.001 | |
| ≥400 | 11.33 (3.27 – 39.18) | <0.001 | 11.54 (3.36 – 39.65) | <0.001 | |
| Log (CAC+1) | 1.40 (1.22 – 1.60) | <0.001 | 1.40 (1.22 – 1.60) | <0.001 | |
| ASCVD High Risk (PCE) | 148 | ||||
| 0 | Ref | Ref | Ref | Ref | |
| 1 to 99 | 1.29 (0.48 – 3.50) | 0.611 | 1.33 (0.49 – 3.65) | 0.576 | |
| 100 to 399 | 1.78 (0.68 – 4.61) | 0.237 | 1.79 (0.69 – 4.66) | 0.234 | |
| ≥400 | 3.64 (1.48 – 9.02) | 0.005 | 3.55 (1.43 – 8.83) | 0.006 | |
| Log (CAC+1) | 1.39 (1.21 – 1.60) | <0.001 | 1.37 (1.22 – 1.56) | <0.001 | |
| ASCVD Low/Borderline Risk (PREVENT) | 50 | ||||
| 0 | Ref | Ref | Ref | Ref | |
| 1 to 99 | 2.56 (1.11 – 5.90) | 0.027 | 2.46 (1.07 – 5.65) | 0.035 | |
| 100 to 399 | 4.52 (1.86 – 11.01) | 0.001 | 4.20 (1.69 – 10.44) | 0.002 | |
| ≥400 | 15.51 (6.01 – 40.05) | <0.001 | 14.53 (5.56 – 37.96) | <0.001 | |
| Log (CAC+1) | 1.42 (1.22 – 1.64) | <0.001 | 1.40 (1.20 – 1.63) | <0.001 | |
| ASCVD Intermediate Risk (PREVENT) | 105 | ||||
| 0 | Ref | Ref | Ref | Ref | |
| 1 to 99 | 3.73 (1.09 – 12.75) | 0.036 | 3.64 (1.07 – 12.41) | 0.039 | |
| 100 to 399 | 7.55 (2.27 – 25.07) | 0.001 | 6.98 (2.12 – 23.01) | 0.001 | |
| >400 | 12.92 (3.88 – 43.06) | <0.001 | 11.53 (3.51 – 37.91) | <0.001 | |
| Log (CAC+1) | 1.46 (1.28 – 1.66) | <0.001 | 1.43 (1.26 – 1.62) | <0.001 | |
| ASCVD High Risk (PREVENT) | 105 | ||||
| 0 | Ref | Ref | Ref | Ref | |
| 1 to 99 | 1.33 (0.43 – 4.12) | 0.623 | 1.41 (0.45 – 4.45) | 0.561 | |
| 100 to 399 | 1.49 (0.50 – 4.43) | 0.477 | 1.53 (0.51 – 4.62) | 0.449 | |
| ≥400 | 2.86 (1.01 – 8.08) | 0.047 | 2.89 (1.01 – 8.28) | 0.048 | |
| Log (CAC+1) | 1.32 (1.13 – 1.55) | <0.001 | 1.31 (1.12 – 1.52) | 0.001 |
A:
Adjusted for age, sex, and study site.
B:
Adjusted for age, sex, study site, HTN, HLD, family history, DM, smoker.