TABLE 3.

Commonly prescribed antihypertensive WM combinations and guideline concordance.

Internet hospitals					Guidelines
Prescribed WM combination	Classes	Support (%)	Confidence (%)	Lift	2017 ACC/AHA guideline	2018 ESC/ESH guideline	2018 Chinese guideline
Dual therapy
Nifedipine + Metoprolol tartrate	A + B	18.65	8.43	0.68	✓	✓	✓
Nifedipine + Candesartan cilexetil	A + C	18.65	6.74	0.65	✓	✓	✓
Nifedipine + Amlodipine Besylate	A + A	18.65	5.87	0.53	✕	✕	✕
Metoprolol tartrate + Candesartan cilexetil	B + C	12.46	7.25	0.7	✕	✓	✓
Metoprolol tartrate + Amlodipine Besylate	B + A	12.46	6.59	0.6	✓	✓	✓
Candesartan cilexetil + Amlodipine Besylate	C + A	10.99	6.07	0.59	✓	✓	✓
Felodipine + nifedipine	A + A	6.02	10.18	0.55	✕	✕	✕
Felodipine + Metoprolol tartrate	A + B	6.02	8.39	0.67	✓	✓	✓
Felodipine + Candesartan cilexetil	A + C	6.02	6.81	0.66	✓	✓	✓
Felodipine + Amlodipine Besylate	A+ A	6.02	5.92	0.54	✕	✕	✕
Triple therapy
Nifedipine + Metoprolol tartrate + Candesartan cilexetil	A + B + C	1.57	5.13	0.5	✕	✓	✓
Nifedipine + Metoprolol tartrate + Amlodipine Besylate	A + B+ A	0.82	6.18	0.33	✕	✕	✕
Candesartan cilexetil + Amlodipine Besylate + Metoprolol tartrate	C+ A + B	0.67	5.65	0.45	✕	✓	✓
Candesartan cilexetil + Amlodipine Besylate + nifedipine	C + A + A	0.67	5.39	0.29	✕	✕	✕
Felodipine + nifedipine + Metoprolol tartrate	A + A + B	0.61	5.08	0.41	✕	✕	✕
Felodipine + nifedipine + Candesartan cilexetil	A + A + C	0.61	3.75	0.36	✕	✕	✕
Felodipine + nifedipine + Metoprolol tartrate	C + A + B	0.60	5.83	0.47	✕	✓	✓
Felodipine + nifedipine + Amlodipine Besylate	C + A + A	0.60	3.97	0.36	✕	✕	✕
Candesartan cilexetil + Metoprolol tartrate + nifedipine	C+ B + A	0.59	4.29	0.42	✕	✓	✓
Candesartan cilexetil + Metoprolol tartrate + Felodipine	C + B + A	0.51	6.28	0.61	✕	✓	✓

Note: A, CCBs; B, Beta-blockers; C, ARBs; ✓: Concordance with guideline recommendations; ✕: Discordant with guideline recommendations.