Table 5.
Binary logistic regression analysis of association between mid-pregnancy plasma glucose levels and adverse pregnancy outcomes (excluded participants with elderly parturient, assisted reproduction, gestational hypertension, and gestational thyroid disorders).
| Variable | n (%) | Crude | Adjusted | ||
|---|---|---|---|---|---|
| OR (95%CI) | P | OR (95%CI) | P | ||
| GDM | <0.001 | <0.001 | |||
| No | 29805 (79.6) | 1 (Ref) | 1 (Ref) | ||
| Yes | 7618 (20.4) | 1.20 (1.13-1.27) | 1.17 (1.10-1.24) | ||
| OGTT 0h | <0.001 | <0.001 | |||
| <5.1 mmol/L | 33682 (90.0) | 1 (Ref) | 1 (Ref) | ||
| ≥5.1 mmol/L | 3741 (10.0) | 1.18 (1.09-1.28) | 1.15 (1.06-1.24) | ||
| OGTT 1h | <0.001 | <0.001 | |||
| <10 mmol/L | 34067 (91.0) | 1 (Ref) | 1 (Ref) | ||
| ≥10 mmol/L | 3356 (9.0) | 1.37 (1.26-1.48) | 1.33 (1.23-1.44) | ||
| OGTT 2h | <0.001 | <0.001 | |||
| <8.5 mmol/L | 34573 (92.4) | 1 (Ref) | 1 (Ref) | ||
| ≥8.5 mmol/L | 2850 (7.6) | 1.28 (1.17-1.39) | 1.24 (1.14-1.36) | ||
| OGTT groups | |||||
| Group 1 | 29805 (79.6) | 1 (Ref) | 1 (Ref) | ||
| Group 2 | 2892 (7.7) | 1.10 (1.00-1.20) | 0.048 | 1.07 (0.98-1.17) | 0.14 |
| Group 3 | 3877 (10.4) | 1.19 (1.10-1.29) | <0.001 | 1.17 (1.08-1.26) | <0.001 |
| Group 4 | 849 (2.3) | 1.61 (1.39-1.87) | <0.001 | 1.54 (1.32-1.78) | <0.001 |
| P for trend | <0.001 | <0.001 | |||
GDM, gestational diabetes mellitus; OGTT, oral glucose tolerance test. Group 1 represents normal plasma glucose at 0h, 1h and 2h; Group 2 represents abnormal plasma glucose at 0h, but normal plasma glucose at 1h and 2h; Group 3 represents normal plasma glucose at 0h, but abnormal plasma glucose at 1h or 2h; Group 4 represents abnormal plasma glucose at 0h, 1h or 2h. Adjusted for maternal age, gravidity, parity, delivery mode and infant sex. Bold represents P values less than 0.05.