Table 6.
Binary logistic regression analysis of association between mid-pregnancy plasma glucose levels and different types of adverse pregnancy outcomes (excluded participants with elderly parturient, assisted reproduction, gestational hypertension, and gestational thyroid disorders).
| Variable | PTB | LBW | Macrosomia | SGA | LGA | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Adjusted | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P |
| GDM | 0.016 | 0.038 | <0.001 | 0.36 | <0.001 | |||||
| No | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | |||||
| Yes | 1.15 (1.03-1.29) | 1.15 (1.01-1.31) | 1.28 (1.12-1.46) | 1.05 (0.95-1.16) | 1.23 (1.14-1.33) | |||||
| OGTT 0 h | 0.53 | 0.41 | <0.001 | 0.94 | <0.001 | |||||
| <5.1 mmol/L | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | |||||
| ≥5.1 mmol/L | 1.05 (0.90-1.22) | 1.08 (0.90-1.28) | 1.37 (1.15-1.61) | 1.01 (0.87-1.15) | 1.26 (1.15-1.39) | |||||
| OGTT 1 h | <0.001 | 0.001 | <0.001 | 0.50 | <0.001 | |||||
| <10 mmol/L | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | |||||
| ≥10 mmol/L | 1.43 (1.23-1.65) | 1.32 (1.11-1.56) | 1.53 (1.29-1.80) | 1.05 (0.91-1.21) | 1.38 (1.24-1.52) | |||||
| OGTT 2 h | 0.001 | 0.06 | 0.006 | 0.17 | <0.001 | |||||
| <8.5 mmol/L | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | |||||
| ≥8.5 mmol/L | 1.30 (1.11-1.53) | 1.20 (0.99-1.44) | 1.31 (1.08-1.57) | 1.11 (0.95-1.29) | 1.29 (1.15-1.44) | |||||
| OGTT groups | ||||||||||
| Group 1 | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | 1 (Ref) | |||||
| Group 2 | 0.93 (0.77-1.11) | 0.44 | 1.04 (0.85-1.27) | 0.69 | 1.12 (0.91-1.37) | 0.27 | 1.05 (0.90-1.22) | 0.54 | 1.15 (1.02-1.29) | 0.019 |
| Group 3 | 1.22 (1.05-1.41) | 0.008 | 1.19 (1.00-1.41) | 0.042 | 1.17 (0.97-1.39) | 0.09 | 1.08 (0.94-1.23) | 0.26 | 1.17 (1.06-1.30) | 0.002 |
| Group 4 | 1.60 (1.22-2.06) | <0.001 | 1.30 (0.93-1.77) | 0.11 | 2.34 (1.78-3.03) | <0.001 | 0.90 (0.66-1.19) | 0.47 | 1.81 (1.51-2.15) | <0.001 |
| P for trend | <0.001 | 0.015 | <0.001 | 0.53 | <0.001 | |||||
GDM, gestational diabetes mellitus; OGTT, oral glucose tolerance test; PTB, preterm birth; LBW, low birth weight; SGA, small for gestational age; LGA, large for gestational age. Group 1 represents normal plasma glucose at 0h, 1h and 2h; Group 2 represents abnormal plasma glucose at 0h, but normal plasma glucose at 1h and 2h; Group 3 represents normal plasma glucose at 0h, but abnormal plasma glucose at 1h or 2h; Group 4 represents abnormal plasma glucose at 0h, 1h or 2h. Adjusted for maternal age, gravidity, parity, delivery mode and infant sex. Bold represents P values less than 0.05.