TABLE 2.
Putative homologues of membrane trafficking proteins identified in the genomes of T. brucei and L. major
| Transport pathway | Class | Protein | EBI database homolog (reference) ina:
|
|
|---|---|---|---|---|
| T. brucei | L. major | |||
| ER to Golgi | COPII | Sec13p | ND | AQ902337 |
| Sec23p | AZ212341, AQ941243, AQ946342, AQ942118, AZ215819 | AQ902560 | ||
| Sec24p | AQ639904, AQ659295, AQ660713, AQ657751 | ND | ||
| Rab GTPase | Rab1 | AQ656291 | L12031 (56) | |
| Rab2 | AQ661511 | ND | ||
| SNAREs | Syntaxin 5 | AQ643295 | ||
| Golgi to ER, intra-Golgi | COPI | α-COP | AL441840 | AQ852115 |
| β-COP | AJ271083b | ND | ||
| β′-COP | AJ250726c | ND | ||
| γ-COP | AQ641446 | ND | ||
| ζ-COP | AJ271084b | AC021894d | ||
| Rab GTPase | Rab6 | AC008031 | AC084317e | |
| Post-Golgi | Clathrin | Clathrin heavy chain | AQ948970, AQ948967, AQ652557 | ND |
| AQ652561, AQ941349, AQ644077 | ||||
| Dynamin-2 | AQ646871, AQ950923 | ND | ||
| AP1 adaptors | γ-Adaptin | AQ649197, AQ649199 | ND | |
| β-Adaptin | AF152173 (221) | AQ843984, AQ844080 | ||
| μ1 chain | AQ949131 | |||
| σ1 chain | AQ655666, AZ213671 | ND | ||
| AP3 adaptors | δ-Adaptin | AQ654960, AQ652661, AQ947042 | ND | |
| μ3 chain | AQ945902, AQ641127 | ND | ||
| σ3 chain | AQ637868 | ND | ||
| Endosome to Golgi | Retromer | Vps5p | AA736241 | AC013257e |
| Vps26p | AQ950582 | ND | ||
| Vps29p | AQ952117 | ND | ||
| Vps35p | AQ653574, AQ940473 | AL446005 | ||
| Endocytosis, endosomal transport | AP2 adaptors | α-Adaptin | ND | AQ849482, AQ849788 |
| AP4 adaptors | δ-Adaptin | AQ654960, AQ652661, AQ947042 | ||
| Rab GTPase | Rab4 | U24677 (89) | AL499614 | |
| Rab5 | U24678 (89) | AL359774 | ||
| Rab7 | AF146042 | AL139262 (161) | ||
| Rab11 | AF152531 (163, 177) | ND | ||
| Sec1-like | Munc18 | AQ639772, AQ639299 | ||
| Vps33p | B07420 | |||
| Vps45p | AQ948874 | |||
| SNAREs | Syntaxin 16 | AQ643792, AQ651850 | AQ848167 | |
| NSF | AL359782 | AL354272 | ||
T. brucei and L. major sequence databases, located at the European Bioinformatics Institute (EBI; http://www.ebi.ac.uk/blast2/parasites.html), were searched for sequences that showed significant homology to proteins involved in membrane trafficking. Four additional Rab GTPases were identified: Rab18 (T. brucei, AF131291 [163, 177]), Rab21 (T. brucei, AL359774), Rab23 (L. major, AQ848776), and Rab28 (T. brucei, AA960734). ND, not detected.
A. G. Maier, S. Schulreich, M. Bremser, and C. Clayton, unpublished GenBank sequence.
H. D. Webb, A. F. Gaud, and M. Carrington, unpublished GenBank sequence.
P. J. Myler, E. Sisk, J. Cawthra, F. Handley, C. Vogt, L. Robertson, P. McDonagh, and K. Stuart, unpublished GenBank sequence.
P. J. Myler, E. Sisk, J. Ruiz, P. Cosenza, A. Cruz, K. Stuart, and E. A. Worthey, unpublished GenBank sequence.