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. 2002 Jun;66(2):300–372. doi: 10.1128/MMBR.66.2.300-372.2002

FIG. 6.

FIG. 6.

Model for the mechanisms with which the HOG pathway controls gene expression via Sko1p. Protein kinase A activity stimulates nuclear localization; some redistribution of Sko1/Acr1p to the cytosol is only observed under severe osmotic stress. Sko1/Acr1p may also have an activating function in addition to its demonstrated role as a repressor.