TABLE 5.
Sensitivity and Resistance pattern of isolated fungal pathogens.
| Drug | Fungal pathogens | p | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Non albicans species (not classified) (n = 30) | Candida albicans (n = 768) | Candida tropicalis (n = 527) | Candida glabrata (n = 50) | Candida krusei (n = 12) | Candida parapsilosis (n = 35) | Candida gulliermondii (n = 10) | Total (n = 1432) | |||
| Amphotericin B | Sensitive | 28 (93.3%) | 767 (99.9%) | 520 (98.7%) | 44 (88.0%) | 9 (75%) | 35 (100%) | 10 (100%) | 1413 (98.7%) | < 0.001*** |
| Resistant | 2 (6.7%) | 1 (0.1%) | 7 (1.3%) | 6 (12.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 16 (1.1%) | ||
| Intermediate sensitivity | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 3 (25.0%) | 0 (0.0%) | 0 (0.0%) | 3 (0.2%) | ||
| Caspofungin | Sensitive | 24 (80.0%) | 765 (99.6%) | 519 (37.0%) | 43 (3.1%) | 8 (0.6%) | 35 (2.5%) | 10 (0.7%) | 1404 (98.0%) | < 0.001*** |
| Resistant | 0 (0.0%) | 3 (0.4%) | 8 (1.5%) | 3 (6.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 14 (1.0%) | ||
| Intermediate sensitivity | 6 (20.0%) | 0 (0.0%) | 0 (0.0%) | 4 (8.0%) | 4 (33.3%) | 0 (0.0%) | 0 (0.0%) | 14 (1.0%) | ||
| Micafungin | Sensitive | 30 (100.0%) | 765 (99.6%) | 520 (98.7%) | 49 (98.0%) | 12 (100.0%) | 35 (100.0%) | 10 (100.0%) | 1421 (99.2%) | NS |
| Resistant | 0 (0.0%) | 3 (0.4%) | 7 (1.3%) | 1 (2.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 11 (0.8%) | ||
| Fluconazole | Sensitive | 28 (93.3%) | 763 (99.3) | 511 (97.0%) | 25 (50.0%) | 4 (33.3%) | 35 (100.0%) | 9 (90.0%) | 1375 (96.0%) | < 0.001*** |
| Resistant | 2 (6.7%) | 5 (0.7%) | 16 (3.0%) | 25 (50.0%) | 8 (66.7%) | 0 (0.0%) | 1 (10.0%) | 57 (4.0%) | ||
| Voriconazole | Sensitive | 30 (100.0%) | 764 (99.5%) | 514 (97.5%) | 47 (94.0%) | 12 (100.0%) | 35 (100.0%) | 10 (100.0%) | 1412 (98.6%) | < 0.01** |
| Resistant | 0 (0.0%) | 4 (0.5%) | 13 (2.5%) | 3 (6.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 20 (1.4%) | ||
| Flucytosine | Sensitive | 30 (100.0%) | 767 (99.9%) | 520 (98.7%) | 50 (100.0%) | 5 (41.7%) | 35 (100.0%) | 10 (0.7%) | 1417 (99.0%) | < 0.001*** |
| Resistant | 0 (0.0%) | 1 (0.1%) | 7 (1.3%) | 0 (0.0%) | 7 (58.3%) | 0 (0.0%) | 0 (0.0%) | 15 (1.0%) | ||
**
p < 0.01.
***
p < 0.001.