TABLE 2.

Alleles having effects on sporulation and/or sterigmatocystin production.

Allele(s)	Function	Mutation effect	Reference(s)
aflR	Pathway-specific regulator of stc gene expression		91
ΔaflR		Loss of sterigmatocystin-aflatoxin production	29, 92, 131
		Affects conidiation and sclerotial development	25, 97, 108, 120
OEaflR		Early and increased mycotoxin production	106
brlA	Pathway-specific regulator of conidiogenesis genes		31
ΔbrlA		Abolishment of conidiation	17, 58
OEbrlA		Early onset of conidiation, including sporulation in submerged liquid culture; no effect on sterigmatocystin production	8
fluG	Involved in synthesis of extracellular, diffusible factor required for conidiation		69
ΔfluG		Aconidial; no sterigmatocystin production	55
OEfluG		Activates conidiation; early sterigmatocystin production observed in submerged liquid culture but not on plates	55
flbA	Encodes RGS-containing protein; active FlbA inactivates G-protein pathway		70
ΔflbA		Aconidial; no sterigmatocystin production	55
OEflbA		Premature sporulation, early sterigmatocystin production	55
fadA	α-Subunit of heterotrimeric G protein		133
ΔfadA and fadAG203R		Premature conidiation; early sterigmatocystin production	55
fadAG42R		Aconidial; no sterigmatocystin production	55
pkaA	cAMP-dependent PKA		106
ΔpkaA		Results in hypersporulation; aberrant sterigmatocystin production	106
OE pkaA		Decreased conidiation; no sterigmatocystin production	106
ΔpkaA ΔflbA		Double deletion mutant; partially restores some sporulation; restores sterigmatocystin production	106
ΔpkaA fadAG42R		Partially restores sporulation but not sterigmatocystin production	106
sfaD	β-Subunit of heterotrimeric G-protein		99
ΔsfaD		Increased sporulation	105

^aΔ indicates the gene has been deleted. OE indicates the gene is overexpressed. fadA^G203R is the dominant negative fadA allele. fadA^G42R is the dominant activated fadA allele.