Table 3.
Pathologic findings of cohort
|
Variables Mean±SD or % |
Non-coal miners | Coal miners | p-value | ||
|---|---|---|---|---|---|
| Lung tissue available,a,b |
Never smokers (n=46) |
Ever-smokers (n=148) |
Never smokers (n=15) |
Ever-smokers (n=66) |
|
| Coal-workers’ pneumoconiosis, % | 0 | 0 | 60.0 | 27.3 | .04 |
| Fibrosis, % | 10.9 | 27.7 | 46.7 | 50.0 | <.01c |
| Usual interstitial pneumonia, % | 0 | 2.0 | 0 | 4.5 | .37 |
| Organizing pneumonia, % | 6.5 | 7.4 | 6.7 | 7.6 | .99 |
| Peribronchiolar metaplasia, % | 2.2 | 10.1 | 6.7 | 4.5 | .23 |
| Respiratory bronchiolitis, % | 0 | 11.5 | 0 | 7.6 | .05 |
| Desquamative interstitial pneumonia, % | 0 | 5.4 | 0 | 7.6 | .22 |
| Anthracosis, % | 10.9 | 56.8 | 80.0 | 65.2 | <.01 |
| Emphysema, % | 23.9 | 71.6 | 33.3 | 66.7 | <.01c |
| Granuloma morphology: | |||||
| Necrotizing, % | 8.7 | 1.4 | 0 | 3.0 | .07 |
| Non-necrotizing (sarcoid-like), % | 6.5 | 4.7 | 6.7 | 7.6 | .86 |
| Calcified, % | 0 | 4.7 | 0 | 3.0 | .57 |
| Chronic inflammation, % | 4.4 | 1.4 | 6.7 | 13.6 | <.01c |
aIndividuals may have more than one pathologic finding
bCWP morphology patterns reported on pathology included coal macule/nodule (n=18), silicotic nodule (n=6), and PMF (n=8)
cSignificant p-value with adjusted α=<.016 as per Bonferroni correction