Table 4:
Multivariate logistic regression model predicting significant associations between radiologic and histologic findings and exposures in the coal miner cohort
| Composite smoking pack ≥30 years | Coal mine work duration ≥30 years | Silica exposure | Asbestos exposure | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Emphysema | ||||||||||||
| Radiologic | 11.06 | 6.64–18.40 | <.001 | |||||||||
| Histologic | 3.80 | 2.20–6.56 | <.001 | |||||||||
| ILDs | ||||||||||||
| Any ILD (not including RB-ILD) | 3.67 | 2.38–5.65 | <.001 | 1.73 | 1.12–2.67 | .01 | 2.03 | 1.15–3.58 | .01 | |||
| RB-ILD (including small opacities disease) | 0.33 | 0.16–0.68 | .002 | 5.99 | 3.15–11.41 | <.001 | 3.18 | 1.61–6.29 | <.001 | |||
| CPFE | 10.4 | 4.49–24.34 | <.001 | 2.44 | 1.24–4.78 | .009 | ||||||
| Histologic fibrosis | 2.62 | 1.48–4.61 | <.001 | 3.27 | 1.65–6.48 | <.001 | ||||||
| CWP | ||||||||||||
| Radiologic simple CWP | 3.51 | 2.15–5.73 | 0 | |||||||||
| Radiologic complicated CWP | 0.52 | 0.29–0.90 | .02 | 5.49 | 3.19–9.41 | 0 | 3.53 | 1.91–6.51 | <.001 | |||
| Histologic CWP | 0.21 | 0.06–0.69 | .01 | 19.30 | 6.45–57.69 | 0 | ||||||
| Histologic anthracosis | 2.45 | 1.48–4.06 | <.001 | 1.99 | 1.01–3.96 | .05 | ||||||
| Dilated main pulmonary artery (CT ratio PA/Ao> 0.90) | 1.58 | 1.05–2.38 | .03 | |||||||||
| Pleural plaque/thickening (radiologic) | 4.98 | 2.63–9.41 | <.001 | |||||||||
CWP coal workers’ pneumonoconiosis, CPFE combined pulmonary fibrosis with emphysema, ILD interstitial lung disease, OR odds ratio (unadjusted), PA/Ao ratio of main pulmonary artery trunk and ascending aorta diameter, RB-ILD respiratory bronchiolitis-ILD