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. 2025 May 15;26:475. doi: 10.1186/s12891-025-08706-9

Table 1.

General characteristics of the included studies

Author Year Study Design Country Biomarker Sample Gender Age (years)
Salek et al. [27] 2010 Case-control Dhakar Metabolism

FSG = 30

CG = 30

Male and female

FSG = 56.77 ± 8.07

CG = 56.77 ± 8.07

Kabbabe et al. [28] 2010 Case-control Australia Inflammation

Gfs = 13

Gc = 10

Male and female Not specified
Xu et al. [29] 2012 Basic science study, Molecular Biology Australia Inflammation

FSG = 8

RTCG = 10

Male and female

FSG = 58 ± 2.25

RTCG = 51 ± 12.5

Kim et al. [30] 2013 Basic science study, Molecular Biology Korea Inflammation

FSG = 13

CG = 6

Male and Female

FSG = 52.6 ± 7.25

CG = 40.1 ± 9.75

Lubis et al. [31] 2013 Biology Indonesia Inflammation

FSG = 50

CG = 50

Male AND female

FSG = 49.5 ± 10

CG = 53.5 ± 6

Lho et al. [32] 2013 Basic science study, molecular and cell Korea Inflammation

GFS = 14

GC = 7

Male AND female  Not specified
Sung et al. [33] 2014 Case-control Korea Metabolism

Fsg = 300

Gc = 900

Male AND female

FSG = 54.01 ± 8.4

CG = 54.01 ± 8.47

Schiefer et al.[34] 2017 Case-control Brazil Metabolism

FSG = 93

CG = 151

Male and female

FSG = 56.26 ± 8.61

CG = 52.32 ± 17.23

Safran et a l[35] 2017 Case series Israel Metabolism GFS = 50 Male and Female FSG = 51 ± 5.4
Chan et al. [36] 2017 Case series, prognosis USA METABOLISM

FSG = 197

CG = 4795

Male and female

FSG = 62.0 ± 18.8

CG = 62.0 ± 18.8

Chen A et al. [37] 2017 Case-control UK Inflammation

FSG = 42

CG = 50

Male and female

FSG = 53.86 ± 1.60

CG = 54.80 ± 2.58

Yano et al. [38] 2020 Basic Science; Molecular and Cell Biology Japan Inflammation

FSG = 33

RCTG = 25

Male and female

FSG: 62.0 ± 7.3

RCTG: 56.4 ± 5.8

Park et al. [39] 2020 Prognostic study: case and control Korea Metabolism

FSG = 151

CG = 453

Male and female

FSG = 52.1 ± 7.2

CG = 52.1 ± 7.2

Mertens et al. [40] 2024 Cross-sectional Belgium Metabolism

FSG = 35

CG = 35

Male and female

FSG = 53.40 ± 8.95

CG = 52.60 ± 6.93

Chen B et al. [41] 2024 Mendelian randomization China Metabolism FSG = 28,416 (Biobank samples) Male and Female * As biobank samples, there is no age limit*

Abbreviations: FSG Frozen Shoulder Group, CG Control Group, RTCG Rotator Cuff, RCTG Rotator Cuff Tear. Age is expressed as mean ± standard deviation