Table 3.

Metabolic pathway analysis.

S. no.	Pathways	P value	Holm p	FDR	Impact
1	Phenylalanine, tyrosine and tryptophan biosynthesis	0.074	1	0.215	1
2	Phenylalanine metabolism	0.074	1	0.215	0.35
3	Biotin metabolism	0.205	1	0.444	0.2
4	Cysteine and methionine metabolism	0.219	1	0.443	0.15
5	Tyrosine metabolism	0.118	1	0.285	0.13
6	Alanine, aspartate and glutamate metabolism	0.356	1	0.509	0.13
7	Pentose and glucuronate interconversions	0.002	0.07	0.019	0.10
8	Vitamin B6 metabolism	0.027	0.66	0.133	0.07
9	Citrate cycle (TCA cycle)	0.869	1	0.933	0.05
10	Porphyrin metabolism	0.975	1	0.975	0.05

Pathway analysis was performed using MetaboAnalyst 6.0. to identify pathways that were significantly altered after HA exposure. Here, p value: The original p value calculated from pathway analysis; Holm p: p values adjusted by the Holm–Bonferroni method; FDR, false discovery rate; Impact, represents a combination of the centrality and pathway enrichment result.