Table 4.

List of the most significant SMPDB pathways.

S. No	Metabolite set	Total	Hits	Expect	p value	Holm P	FDR
1	Tryptophan metabolism	59	7	2.18	0.004	0.429	0.429
2	Catecholamine biosynthesis	20	3	0.74	0.034	1	1
3	Arginine and proline metabolism	52	5	1.92	0.038	1	1
4	Carnitine synthesis	22	3	0.81	0.044	1	1

SMPDB Pathway analysis was performed using MetaboAnalyst 6.0. to identify pathways that were significantly altered after HA exposure. Here, Total: Total number of compounds in the pathways; Hits: Number of compound matched from our data; p Value: The original p value calculated from pathway analysis; Holm p: p Values adjusted by the Holm–Bonferroni method; FDR, false discovery rate.