FIGURE 2.

Cross‐sectional volumetric changes. T‐statistic maps (p‐FDR < 0.05) illustrate cross‐sectional differences (term Dx in the LME), overlaid on the MNI template. Panels display: patients with ALS versus HCs (A) ALS_short versus HCs (B), ALS_long versus HCs (C), and ALS_short versus ALS_long (D). “ALS_short” and “ALS_long” refer to patients who experienced the event prior to and after 24 months respectively. HCs represent healthy controls. Warmer colors highlight regions of enlargement (eg, ventricular and sulcal regions), while cooler colors indicate areas of tissue atrophy. Sample sizes: ALS (n = 175), HCs (n = 165), ALS_short (n = 41), ALS_long (n = 60). ALS = amyotrophic lateral sclerosis; ALS_long = ALS long survival time ALS_short = ALS short survival time; Dx = diagnosis; FDR = false discovery rate; HC = healthy controls; LME = linear mixed effect; MNI = Montreal Neurological Institute. [Color figure can be viewed at www.annalsofneurology.org]