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. 2025 May 16;15(21):16455–16467. doi: 10.1039/d5ra02261d

Table 1. HRMS-derived molecular and ion data as well as the yields for ginsenoside Re transformation products in aqueous methanol.

Peak Identification Relative molecular mass Molecular formula Measured [M − H]− (m/z) Fragment ions Yield (%)
1 20(S)-25-OH-Rh1 656.6572 C36H63O10 655.6572 493.5664[M-Glc-H]−, 475.5215[M-Glc-H2O-H]−, 417.5839[M-Glc-C3H8O2-H]−, 391.4672[M-Glc-C6H14O-H]− 2.51
2 20(S)-Rf2 802.7563 C42H73O14 801.7563 655.6321[M-Rha-H]−, 637.6381[M-Rha-H2O-H]−, 493.5871[M-Rha-Glc-H]−, 475.5267[M-Glc-Rha-H2O-H]−, 417.5835[M-Rha-Glc-C3H8O2-H]−, 391.4662[M-Glc-Rha-C6H14O]− 4.11
3 20(R)-Rf2 802.7561 C42H73O14 801.7561 655.6329[M-Rha-H]−, 637.6385[M-Rha-H2O-H]−, 493.5873[M-Rha-Glc-H]−, 475.5361[M-Glc-Rha-H2O-H]−, 417.5830[M-Rha-Glc-C3H8O2-H]−, 391.4669[M-Glc-Rha-C6H14O]− 6.44
4 20(R)-25-OH-Rh1 656.6577 C36H63O10 655.6577 493.5668[M-Glc-H]−, 475.5210[M-Glc-H2O-H]−, 417.5830[M-Glc-C3H8O2-H]−, 391.4678[M-Glc-C6H14O-H]− 3.72
5 20(S)-25-OCH3-Rg2 816.7441 C43H74O14 815.7441 669.6326[M-Rha]−, 651.6182[M-Rha-H2O-H]−, 507.5326[M-Glc-Rha-H]−, 475.5263[M-Glc-Rha-H]−, 457.5[M-Glc-Rha-CH3OH-H2O-H]−, 391.4663[M-Glc-Rha-C7H16O-H]− 2.47
6 20(R)-25-OCH3-Rg2 816.7440 C43H74O14 815.7440 669.6325[M-Rha-H]−, 651.6180[M-Rha-H2O-H]−, 507.329[M-Glc-Rha-H]−, 475.5261[M-Glc-Rha-CH3OH-H]−, 457.5[M-Glc-Rha-CH3OH-H2O-H]−, 391.4662[M-Glc-Rha-C7H16O-H]− 4.55
7 20(S)-25-OCH3-Rh1 670.6310 C37H65O10 669.6310 507.5321[M-Glc-H]−, 475.5263[M-Glc-CH3OH-H]−, 457.5132[M-Glc-CH3OH-H]−, 391.4661[M-Glc-C7H16O-H]− 2.25
8 20(S)-OCH3-25-OH-Rg2 816.7442 C43H74O14 815.7442 669.6321[M-Rha-H]−, 651.6183[M-Rha-H2O-H]−, 507.5326[M-Glc-Rha-H]−, 475.5262[M-Glc-Rha-CH3OH-H]−, 417.5[M-Glc-Rha-C4H10O2-H]− 7.91
9 20(R)-25-OCH3-Rh1 670.6311 C37H65O10 669.6311 507.5325[M-Glc-H]−, 475.5264[M-Glc-CH3OH-H]−, 457.5133[M-Glc-CH3OH-H]−, 391.4662[M-Glc-C7H16O-H]− 3.25
10 20(R)-OCH3-25-OH-Rg2 816.7441 C43H74O14 815.7441 669.6324[M-Rha-H]−, 651.6185[M-Rha-H2O-H]−, 507.5327[M-Glc-Rha-H]−, 475.5263[M-Glc-Rha-CH3OH-H]−, 417.5[M-Glc-Rha-C4H10O2-H]− 0.74
11 25-OH-Rg6 784.7760 C42H71O13 783.7760 637.6122[M-Rha-H]−, 619.6321[M-Rha-H2O-H]−, 475.5131[M-Glc-Rha-H]−, 417.5831[M-Glc-Rha-C3H6O]− 6.33
12 25-OH-F4 784.7761 C42H71O13 783.7761 637.6121[M-Rha-H]−, 619.6322[M-Rha-H2O-H]−, 475.5132[M-Glc-Rha-H]−, 417.5832[M-Glc-Rha-C3H6O]− 4.11
13 20(S)-Rg2 784.7763 C42H71O13 783.7763 637.6124[M-Rha-H]−, 619.6324[M-Rha-H2O-H]−, 475.5133[M-Glc-Rha-H]−, 391.4661[M-Glc-Rha-C6H12-H]− 17.93
14 20(R)-Rg2 784.7761 C42H71O13 783.7761 637.6121[M-Rha-H]−, 619.6320[M-Rha-H2O-H]−, 475.5134[M-Glc-Rha-H]−, 391.4663[M-Glc-Rha-C6H12-H]− 22.53
15 20(S)-Rh1 638.6552 C36H62O9 637.6552 475.5260[M-Glc-H]− 7.07
16 20(R)-Rh1 638.6551 C36H62O9 637.6551 475.5261[M-Glc-H]− 10.42
17 20(S,25)-epoxy-Rg2 784.7760 C42H71O13 783.7760 637.6125[M-Rha-H]−, 619.6320[M-Rha-H2O-H]−, 475.5132[M-Glc-Rha-H]−, 417.5830[M-Glc-Rha-C3H6O-H]−, 391.4[M-Glc-Rha-C6H12-H]− 1.68
18 25-OCH3-Rg6 798.7566 C43H72O13 797.7566 651.6443[M-Rha-H]−, 633.6321[M-Rha-H2O-H]−, 489.5431[M-Glc-Rha-H]−, 457.5131[M-Glc-Rha-CH3OH-H]− 7.25
19 25-OCH3-F4 798.7567 C43H72O13 797.7567 651.6441[M-Rha-H]−, 633.6320[M-Rha-H2O-H]−, 489.5432[M-Glc-Rha-H]−, 457.5132[M-Glc-Rha-CH3OH-H]− 1.67
20 20(R,25)-epoxy-Rg2 784.7761 C42H71O13 783.7761 637.6121[M-Rha-H]−, 619.6324[M-Rha-H2O-H]−, 475.5131[M-Glc-Rha-H]−, 417.5831[M-Glc-Rha-C3H6O-H]−, 391.4[M-Glc-Rha-C6H12-H]− 1.72
21 25-OCH3-Rk3 652.6441 C37H63O9 651.6441 489.5432[M-Glc-H]−, 457.5134[M-Glc-CH3OH-H]− 1.09
22 25-OCH3-Rh4 652.6442 C37H63O9 651.6442 489.5430[M-Glc-H]−, 457.5132[M-Glc-CH3OH-H]− 3.02
23 20(S)-OCH3-Rg2 798.7563 C43H72O13 797.7563 651.6441[M-Rha-H]−, 633.6320[M-Rha-H2O-H]−, 489.5430[M-Glc-Rha-H]−, 457.5134[M-Glc-Rha-CH3OH-H]− 12.31
24 20(R)-OCH3-Rg2 798.7562 C43H72O13 797.7562 651.6442[M-Rha-H]−, 633.6321[M-Rha-H2O-H]−, 489.5433[M-Glc-Rha-H]−, 457.5131[M-Glc-Rha-CH3OH-H]− 4.89
25 Rg6 766.7134 C42H69O12 765.7134 619.6321[M-Rha-H]−, 601.6550[M-Rha-H2O-H]−, 457.5131[M-Glc-Rha-H]− 17.54
26 20(S)-OCH3-Rh1 652.6443 C37H63O9 651.6443 489.5430[M-Glc-H]−, 457.5131[M-Glc-CH3OH-H]− 3.54
27 F4 766.7132 C42H69O12 765.7132 619.6324[M-Rha-H]−, 601.6551[M-Rha-H2O-H]−, 457.5133[M-Glc-Rha-H]− 16.63
28 20(R)-OCH3-Rh1 652.6445 C37H63O9 651.6445 489.5431[M-Glc-H]−, 457.5135[M-Glc-CH3OH-H]− 0.76
29 Rk3 620.6442 C36H60O8 619.6442 457.5138[M-Glc-H]− 6.97
30 Rh4 620.6441 C36H60O8 619.6441 457.5139[M-Glc-H]− 5.38