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. 2025 May 16;30(5):oyaf084. doi: 10.1093/oncolo/oyaf084

Figure 3.

Two-panel line graph showing cancer incidence rates per 100,000 from 2001 to 2019 for females (left) and males (right), separated by cancer type. Each line represents a different cancer, with a legend including the Average Annual Percent Change (AAPC) and 95% confidence intervals. Asterisks denote statistically significant trends.For females, breast cancer shows the highest and steadily increasing rate (~35–38 per 100,000), followed by thyroid cancer, which increased rapidly until around 2013 and then declined. Colon & rectum and corpus uteri cancers also increased significantly. Cervix uteri cancer showed a slight decline, while melanoma remained relatively stable. For males, thyroid cancer also increased sharply, reaching ~15 per 100,000. Kidney & renal and colon & rectum cancers showed steady increases. Melanoma and non-Hodgkin lymphoma declined significantly. Leukemia and testis cancers increased moderately. The graph highlights sex-specific differences in incidence trends and growth patterns across cancer types.

Early onset cancer incidence rates by sex and cancer type, United States Cancer Statistics Database, 2001-2019. Abbreviations: AAPC, average annual percent change; NH, non-Hodgkin lymphoma; NOS, not otherwise specified. Annual incidence rates in adults, aged 20-49 years, are age-adjusted to the 2000 US standard population. The AAPC for each cancer type was calculated using a weighted average of the slope coefficients of the underlying joinpoint regression line with weights equal to the length of each segment over the interval. AAPCs that were statistically different from zero (P < .05) are indicated with an asterisk.