. 2025 May 16;25:346. doi: 10.1186/s12877-025-06020-6

Table 4.

Diagnostic test evaluation of sarcopenia screening tools

Parameters	Sensitivity (95%CI)	Specificity (95%CI)	PPV (95%CI)	NPV (95%CI)	LR + (95%CI)	LR- (95%CI)	Accuracy (95%CI)	AUC (95%CI)
Calf circumference (M < 34 cm; F < 33 cm)	59.0^a,b (47.3, 70.0)	92.4^a,b,c (88.4, 95.4)	70.8 (58.2, 81.4)	87.9 (83.3, 91.6)	7.79 (4.87, 12.47)	0.44 (0.34, 0.58)	84.5 (80.1, 88.2)	0.892^{1,2,3,4,5,6,7} (0.857, 0.927)
Neck circumference (M < 38 cm; F < 32.8 cm)	33.3^c,d,e (23.1, 44.9)	94.8^d,e,f (91.3, 97.2)	66.7 (51.9, 78.7)	82.1 (79.6, 84.3)	6.44 (3.48, 11.91)	0.70 (0.60, 0.82)	80.2 (75.5, 84.4)	0.785^1,8,9,10,11 (0.728, 0.841)
SARC-F (≥ 4)	25.6^a,f,g,h (16.4, 36.8)	86.1^h,i,j (81.1, 90.1)	36.4 (26.0, 48.2)	78.8 (76.4, 81.1)	1.84 (1.13, 2.99)	0.86 (0.75, 0.99)	71.7 (66.5, 76.5)	0.602^2,8,12,13,14 (0.529, 0.674)
SARC-CalF (≥ 11)	48.7^i,j,k (37.2, 60.3)	93.2^k,l,m (89.4, 96.0)	69.1 (57.3, 78.9)	85.4 (82.5, 87.9)	7.19 (4.31, 12.0)	0.55 (0.44, 0.68)	82.7 (78.1, 86.6)	0.789^3,12,15,16 (0.727, 0.852)
SARCF + EBM (≥ 12)	35.9^l,m,n (25.3, 47.6)	87.7^n,q,o (82.9, 91.5)	47.5 (36.7, 58.5)	81.5 (78.7, 83.9)	2.91 (1.87, 4.53)	0.73 (0.62, 0.87)	75.4 (70.4, 79.9)	0.774^4,13,17,18 (0.715, 0.834)
Hand grip strength (M < 28 kg; F < 18 kg)	80.8^c,f,I,l (70.3, 88.8)	55.8^{a,d,h,k,n,p,r} (49.4, 62.0)	36.2 (32.2, 40.4)	90.3 (85.4, 93.7)	1.83 (1.53, 2.18)	0.34 (0.22, 0.55)	61.7 (56.2, 66.9)	0.716^5,9,14,19 (0.652, 0.781)
5-times chair stand (≥ 12 s)	90.5^b,d,g,j,m (81.5, 96.1)	28.3^b,e,i,l,q,p (22.7, 34.4)	27.7 (25.6, 29.9)	90.8 (82.6, 95.4)	1.26 (1.13, 1.41)	0.33 (0.16, 0.70)	42.8 (37.3, 48.4)	0.657^6,10,15,17 (0.588, 0.725)
Gait speed (< 1 m/s)	84.2^e,h,k,n (74.0, 91.6)	27.6^c,f,j,m,o,r (22.2, 33.6)	26.1 (23.8, 28.6)	85.2 (76.7, 90.9)	1.16 (1.03, 1.32)	0.57 (0.33, 1.00)	40.8 (35.4, 46.4)	0.623^{7,11,16,18,19} (0.548, 0.697)

Parameters

Sensitivity
(95%CI)

Specificity
(95%CI)

PPV
(95%CI)

NPV
(95%CI)

LR +
(95%CI)

LR-
(95%CI)

Accuracy
(95%CI)

AUC
(95%CI)

Calf circumference

(M < 34 cm; F < 33 cm)

59.0^a,b

(47.3, 70.0)

92.4^a,b,c

(88.4, 95.4)

70.8

(58.2, 81.4)

87.9

(83.3, 91.6)

7.79

(4.87, 12.47)

0.44

(0.34, 0.58)

84.5

(80.1, 88.2)

0.892^{1,2,3,4,5,6,7}

(0.857, 0.927)

Neck circumference

(M < 38 cm; F < 32.8 cm)

33.3^c,d,e

(23.1, 44.9)

94.8^d,e,f

(91.3, 97.2)

66.7

(51.9, 78.7)

82.1

(79.6, 84.3)

6.44

(3.48, 11.91)

0.70

(0.60, 0.82)

80.2

(75.5, 84.4)

0.785^1,8,9,10,11

(0.728, 0.841)

SARC-F (≥ 4)

25.6^a,f,g,h

(16.4, 36.8)

86.1^h,i,j

(81.1, 90.1)

36.4

(26.0, 48.2)

78.8

(76.4, 81.1)

1.84

(1.13, 2.99)

0.86

(0.75, 0.99)

71.7

(66.5, 76.5)

0.602^2,8,12,13,14

(0.529, 0.674)

SARC-CalF (≥ 11)

48.7^i,j,k

(37.2, 60.3)

93.2^k,l,m

(89.4, 96.0)

69.1

(57.3, 78.9)

85.4

(82.5, 87.9)

7.19

(4.31, 12.0)

0.55

(0.44, 0.68)

82.7

(78.1, 86.6)

0.789^3,12,15,16

(0.727, 0.852)

SARCF + EBM (≥ 12)

35.9^l,m,n

(25.3, 47.6)

87.7^n,q,o

(82.9, 91.5)

47.5

(36.7, 58.5)

81.5

(78.7, 83.9)

2.91

(1.87, 4.53)

0.73

(0.62, 0.87)

75.4

(70.4, 79.9)

0.774^4,13,17,18

(0.715, 0.834)

Hand grip strength

(M < 28 kg; F < 18 kg)

80.8^c,f,I,l

(70.3, 88.8)

55.8^{a,d,h,k,n,p,r}

(49.4, 62.0)

36.2

(32.2, 40.4)

90.3

(85.4, 93.7)

1.83

(1.53, 2.18)

0.34

(0.22, 0.55)

61.7

(56.2, 66.9)

0.716^5,9,14,19

(0.652, 0.781)

5-times chair stand

(≥ 12 s)

90.5^b,d,g,j,m

(81.5, 96.1)

28.3^b,e,i,l,q,p

(22.7, 34.4)

27.7

(25.6, 29.9)

90.8

(82.6, 95.4)

1.26

(1.13, 1.41)

0.33

(0.16, 0.70)

42.8

(37.3, 48.4)

0.657^6,10,15,17

(0.588, 0.725)

Gait speed (< 1 m/s)

84.2^e,h,k,n

(74.0, 91.6)

27.6^c,f,j,m,o,r

(22.2, 33.6)

26.1

(23.8, 28.6)

85.2

(76.7, 90.9)

1.16

(1.03, 1.32)

0.57

(0.33, 1.00)

40.8

(35.4, 46.4)

0.623^{7,11,16,18,19}

(0.548, 0.697)

Identical letters indicate statistically significant differences at the 0.05 level between sensitivity and specificity by the Marascuillo procedure

Identical numbers indicate statistically significant differences at the 0.05 level between the AUC curves by the DeLong test

PPV Positive Predictive Value, NPV Negative Predictive Value, LR + Positive Likelihood Ratio, LR- Negative Likelihood Ratio, AUC Area under the curve