Table 3.

DDC Induces Cholestatic and Hepatic Damage and Liver Hypertrophy

	Untreated	DDC 7d	DDC 3.5M	Rec 1M	R1M + DDC7d	Rec 3M	R3M + DDC7d
Bilirubin (mg/dL)	0.5 ± 0.4	1.3 ± 1.4	0.6 ± 0.7	0.4 ± 0.2	1.1 ± 1.1	ND	0.5 ± 0.5
ALT (IU/L)	49 ± 24	1,342 ± 1,237	1,170 ± 90	51 ± 13	2,006 ± 452*	ND	987 ± 462*
ALP (IU/L)	90 ± 12*	251 ± 8†	654 ± 77	115 ± 6*	479 ± 50†	ND	496 ± 54†
Liver weight/body weight (%)	4.4 ± 0.2	5.4 ± 1.3	16.6 ± 0.2	7.1 ± 0.4	12.0 ± 0.9	6.1 ± 0.1	8.1 ± 0.4

Sex- and age-matched mice were used (4 to 6 mice per condition). Values are expressed as the mean ± standard deviation.

Abbreviations: ALT, alanine aminotransferase; ALP, alkaline phosphatase; ND, not determined.

^*P = 0.05.

^†P < 0.02 (DDC7d versus DDC refeeding).