Table 2.
Linear Growth Model Results for the Effect of Childhood Trauma Exposure and APOEε4 on Slope and Intercept of Three Frontal Alpha EEG Coherence Pairs and Subsequent AUD and PTSD symptoms in Trauma-Exposed Adolescent Male and Female COGA Participants.
| Left frontal-central (LFC) EEG coherence FZ-CZ--F3-C3 | Right frontal-central (RFC) EEG coherence FZ-CZ--F4-C4 | Prefrontal interhemispheric (PFI) EEG coherence F8-F4--F7-F3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Males | Females | Males | Females | Males | Females | |||||||
| Beta (S.E.) | p | Beta (S.E.) | p | Beta (S.E.) | p | Beta (S.E.) | p | Beta (S.E.) | p | Beta (S.E.) | p | |
| Associations with Intercept and Slope of Alpha EEG Coherence | ||||||||||||
| CNAT on Intercept | −0.05 (0.04) | .198 | −0.05 (0.01) | .001 | −0.04 (0.02) | .045 | −0.04 (0.02) | .015 | −0.04 (0.14) | .785 | −0.02 (0.01) | .116 |
| CSAT on Intercept | 0.24 (0.22) | .282 | 0.10 (0.03) | .002 | 0.03 (0.14) | .844 | 0.12 (0.04) | .002 | 0.048 (0.13) | .701 | 0.13 (0.03) | <.001 |
| CPAT on Intercept | −0.17 (0.08) | .037 | 0.04 (0.03) | .109 | 0.00 (0.03) | .884 | 0.04 (0.02) | .111 | 0.01 (0.08) | .902 | 0.07 (0.03) | .007 |
| APOEε4 on Intercept | −0.11 (0.04) | .003 | −0.07 (0.04) | .066 | −0.05 (0.04) | .216 | −0.08 (0.04) | .024 | −0.07 (0.32) | .827 | 0.06 (0.05) | .207 |
| Parental education on Intercept | 0.00 (0.01) | .844 | −0.00 (0.00) | .674 | 0.01 (0.01) | .582 | −0.00 (0.00) | .397 | 0.00 (0.02) | .875 | −0.00 (0.00) | .201 |
| CNAT on Slope | 0.03 (0.02) | .238 | 0.00 (0.01) | .891 | 0.02 (0.01) | .127 | 0.00 (0.01) | .749 | 0.02 (0.08) | .795 | −0.01 (0.01) | .456 |
| CSAT on Slope | −0.10 (0.12) | .424 | −0.05 (0.02) | .002 | 0.00 (0.08) | .991 | −0.05 (0.02) | .005 | −0.01 (0.07) | .870 | −0.07 (0.02) | <.001 |
| CPAT on Slope | 0.11 (0.05) | .021 | −0.02 (0.01) | .135 | 0.01 (0.02) | .477 | −0.02 (0.01) | .135 | −0.01 (0.05) | .868 | −0.01 (0.02) | .551 |
| APOEε4 on Slope | 0.06 (0.02) | .002 | 0.03 (0.02) | .081 | 0.02 (0.02) | .223 | 0.04 (0.02) | .021 | 0.04 (0.18) | .823 | −0.02 (0.03) | .410 |
| Parental education on Slope | −0.00 (0.01) | .650 | 0.00 (0.00) | .105 | −0.00 (0.01) | .605 | 0.00 (0.00) | .108 | −0.00 (0.01) | .525 | 0.00 (0.00) | .257 |
| Associations with AUD and PTSD Symptoms | ||||||||||||
| Intercept on AUD Symptoms | −0.54 (0.32) | .090 | −0.58 (0.52) | .265 | −1.97 (0.34) | <.001 | −0.82 (0.52) | .115 | −1.64 (9.71) | .866 | 0.457 (0.513) | .373 |
| Slope on AUD Symptoms | −0.13 (0.28) | .641 | −3.51 (1.25) | .005 | 0.29 (1.16) | .805 | −4.21 (1.29) | .001 | 2.14 (1.06) | .044 | −1.028 (0.728) | .158 |
| Intercept on PTSD Symptoms | 0.09 (0.07) | .183 | 0.27 (0.12) | .026 | 0.23 (0.09) | .009 | 0.29 (0.13) | .024 | 0.15 (3.88) | .969 | 1.224 (0.101) | <.001 |
| Slope on PTSD Symptoms | −0.07 (0.07) | .337 | −4.74 (1.17) | <.001 | −0.43 (0.34) | .213 | −4.83 (1.32) | <.001 | −0.71 (0.63) | .262 | −1.799 (0.472) | <.001 |
| APOEε4 on AUD Symptoms | −0.06 (0.08) | .435 | 0.14 (0.11) | .189 | −0.09 (0.12) | .421 | 0.18 (0.13) | .149 | 0.00 (0.08) | .968 | −0.20 (1.63) | .902 |
| APOEε4 on PTSD Symptoms | −0.00 (0.02) | .930 | 0.18 (0.13) | .172 | 0.00 (0.03) | .927 | 0.23 (0.14) | .094 | −0.00 (0.01) | .801 | 0.02 (0.46) | .963 |
| Observations | 408 | - | 459 | - | 408 | - | 459 | - | 408 | - | 459 | - |
| AIC | 3387.67 | - | 4524.20 | - | 3435.75 | - | 4523.34 | - | 3317.11 | - | 4133.07 | - |
| BIC | 3669.45 | - | 4815.32 | - | 3717.53 | - | 4814.46 | - | 3598.89 | - | 4424.20 | - |
| H0 log-likelihood | −1622.84 | - | −2191.10 | - | −1646.87 | - | −2190.67 | - | −1587.55 | - | −1995.54 | - |
| H1 maximum log-likelihood | 10803.47 | - | 20941.41 | - | 10775.14 | - | 12047.75 | - | 10848.44 | - | 12253.71 | - |
Note: CNAT = Childhood non-assaultive trauma, CSAT = Childhood sexual assaultive trauma, CPAT = Childhood physical assaultive trauma. AIC= Akaike Information Criterion, BIC=Bayesian Information Criterion. Bold text indicates p-value less than .05. Bold italic text indicates p-value less than .01.