Table 5.

Treatment-related adverse events (TRAEs) associated with DV

TRAEs	DV monotherapy		DV+PD-1 A
	Grade 1–2	Grade ≥ 3	Grade1–2	Grade ≥ 3
Decreased appetite/anorexia	+		+ +  + +	+
Rash			+ +
Weak/asthenia/debilitation	+		+ +  +
Hypothyroidism			+
Fatigue	+		+ +  +
Gastrointestinal bleeding				+
Intestinal obstruction				+
Peripheral sensory neuropath	+ +	+ +	+ +  + +
Anemia			+ +  +
Immune-related pneumonia				+
Recurrent urinary tract infection				+
Alopecia	+ +		+ +
Leukopenia	+ +		+
Neutropenia	+ +	+ +
Elevated transaminase (AST/ALT)	+ +		+
Bone marrow suppression			+
Nausea/vomiting			+ +  +
Proteinuria			+
Hypoalbuminemia			+

The data of TRAEs are based on the clinical trials listed in Table 1. Statistical analysis was conducted on the basis of the most common TRAEs observed in each clinical trial. “+” represents one occurrence in the enumeration of the most common TRAEs in the corresponding clinical trial regimens