Table 2.
Clinical management and outcomes during initial hospital stay
| All infants with gastroschisis N = 109 [A] |
Abdominal wall closure within five days N = 34 [B] |
Abdominal wall closure more than five days N = 75 [C] |
P-value [B vs C] |
|
|---|---|---|---|---|
| Silo at KEMH | 35/102 (34.3%) | 14/33 (42.4%) | 21/69 (30.4%) | 0.269 |
| Birth to silo application(hours) |
2.71 (2.06, 3.6) N = 101 |
3.0(2.0, 3.7) N = 32 |
2.55(2.,3.6) N = 69 |
0.731 |
|
Silo size 3 4 5 6 |
3(3.2%) 23 (24.7%) 51 (54.8%) 16 (17.2%) N = 93 |
2(7.4%) 12 (44.4%) 13 (48.1%) 0 (0%) N = 27 |
1(1.5%) 11 (16.7%) 38 (57.6%) 16 (26.2%) N = 66 |
0.001 |
| Age at abdominal wall closure (days) | 6 (5, 8) | 4 (3,5) | 7 (6,10) | < 0.0001 |
| Use of Mesh for closing the abdomen | 28/108 (26%) | 2/34 (5.9%) | 26/74 (35.1%) | 0.001 |
| Preoperative ventilation | 71/108 (65.7%) | 18/34 (52.9%) | 53/74 (71.6%) | 0.080 |
| Duration of ventilation (days) | 3 (2, 6.5) | 3 (1, 5) | 4 (2,8) | 0.005 |
| Duration of ventilation in infants who were not ventilated pre-op (days) |
2 (1, 3) N = 37 |
1.5 (1,3) N = 16 |
2 (2, 4) N = 21) |
0.163 |
| Duration of ventilation in infants who were ventilated pre-op (days) |
5 (3, 8) N = 71 |
3.5 (2,5) N = 18 |
6 (3,9) N = 53 |
0.044 |
| Number of days on antibiotics | 15 (11, 22) | 10 (8,14) | 18(13,24) | < 0.0001 |
| Age at commencing PN | 1 (1, 1) | 1 (1,1) | 1(1,1) | 0.909 |
| Duration of PN (days) | 21 (15, 29) | 14 (10.5,23.5) | 24(17, 29) | < 0.0001 |
| Postnatal age at commencing enteral feeds | 10 (7, 13) | 6 (5,8) | 11 (9,14) | < 0.0001 |
| Post-op day at commencing enteral feeds after abdominal wall closure | 3 (2, 4) |
3 (2,3) N = 33 |
3 (3,4) N = 69 |
0.004 |
| Postnatal age at full feeds (days) | 21.5 (15.5, 29) | 15 (12.5,22.5) | 24.5 (17.5,30) | < 0.0001 |
| Days taken to reach full feeds, once commenced | 13 (10, 21) | 11 (9, 19) | 15 (11, 22) | 0.091 |
| Corrected gestational age at discharge (weeks) | 40.4 (38.8, 41.2) | 39.4(38, 40.5) | 40.7(39.8, 41.4) | 0.0005 |
| Discharge weight (g) | 3010 (2640, 3315) | 2937(2460, 3150) | 3010(2705, 3410) | 0.121 |
| Discharge weight centiles | 7.5 (2.5, 25.5) | 7.5(2.5,27.5) | 7.5 (2.5,19.5) | 0.821 |
| Discharge weight z scores | − 1.36 (1.07) | − 1.24(1.24) | − 1.41(0.99) | 0.510 |
| Duration of hospital stay (days) | 29 (20, 38.5) | 19 (15, 30) | 32 (23,43) | < 0.0001 |
| Blood culture positive sepsis | 16/108 (14.8%) | 4/34(11.8%) | 12/74(16.2%) | 0.771 |
| Abdominal compartment syndrome | 3/108(2.8%) | 0/34 | 3/74 (4%) | 0.550 |
| NEC | 2/108 (1.8%) | 1/34 (2.9%) | 1/74 (1.3%) | 0.533 |
| Return to theatre during initial hospital stay | 10/108 (9.2%) | 2/34 (5.9%) | 8/74 (10.8%) | 0.500 |
| Age at return to theatre (days) |
44 (13, 61) range 1, 67 N = 11 |
26.5 (9, 44) N = 2 |
45(19, 61) N = 9 |
0.436 |
| Mortality before discharge | 3/109 (2.7%) | 2/34 (5.9%) | 1/75 (1.3%) | 0.229 |
p value of less than 0.05 was considered as statistically significant
PN Parenteral nutrition, NEC Necrotising enterocolitis