Table 3. In vitro cytotoxicity assay of synthesized compounds with cisplatin as a positive control against the A549 cell line.
| Compounds | IC50a at 24 h (μM) | IC50a at 48 h (μM) |
|---|---|---|
| 4a | 6.6025 ± 0.108 | 3.814 ± 0.02 |
| 4b | 9.023 ± 2.44 | 3.22 ± 0.17 |
| 4c | >100 | 10.26 ± 2.73 |
| 4d | 33.53 ± 0.34 | 14.49 ± 3.18 |
| 4f | >100 | >100 |
| 4e | 6.929 ± 0.271 | 5.5 ± 0.5 |
| 4g | 9.40 ± 0.611 | 3.5 ± 0.13 |
| 5a | 28.90 ± 12.7 | 10.76 ± 1.9 |
| 5b | 64.39 ± 9.8 | 17.39 ± 1.82 |
| 5c | 12.90 ± 2.28 | 8.242 ± 0.34 |
| 5d | 55.61 ± 0.18 | 13.45 ± 1.27 |
| 5e | 15.65 ± 0.063 | 3.48 ± 1.32 |
| 5f | 16.915 ± 3.92 | 1.2 ± 0.412 |
| 5g | 11.06 ± 8.9 | 7.8 ± 2.3 |
| Cisplatin | >50 | 22.35 ± 0.64 |
a
Data are mean% ± SD% of each triplicate.