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. 2025 May 19;15(19):14655–14690. doi: 10.1039/d4ra06937d

Table 1. Different bottom-up synthesis methods of ChNFs and their challenges, application, and cost-effectiveness.

Method Advantages Challenge Principal application Environmental impact Cost Ref.
Electrospinning High surface area, scalable, fine control Specific solvent requirements, costly Textiles, filtration, biomedical Moderate (solvent use, energy) Moderate to high (equipment costs) 48–50
Self-assembly Low-cost, green, simple process Limited control over fiber morphology Sustainable applications, bio-based products Very low (green process) Low (simple process, less equipment) 51 and 52
Hydrothermal/solvothermal High crystallinity, controlled morphology High-energy requirements, expensive Large-scale production, high-performance materials Moderate (energy-intensive) High (specialized equipment, energy) 53 and 54
Biomimetic synthesis Precision, functionalization, biocompatibility High cost, scalability issues, complexity Biomedical, sustainable packaging, cosmetics Low Hight 55 and 56
Enzymatic hydrolysis Biodegradable, environmentally friendly High cost of enzymes, slow process Biodegradable applications, small-scale Very low (biodegradable enzymes) High (enzyme cost, slow process) 57 and 58