Table 5:
Type I error rates and power from different designs for two equally-distributed covariate strata and continuous outcomes using all data from both stages
| Theta | Design | Threshold | Rejection Rate |
|---|---|---|---|
| (0.5, 0, 0.5, 0) | NED1 | 0.048 | |
| SED2 | 0.050 | ||
| ZHU3 | 0.044 | ||
| MCED14 | 0.2 & 0.4 | 0.047 | |
| MCED25 | 0.2 & 0.4 | 0.050 | |
| (0.5, 0, 0.5, 0.2) | NED | 0.160 | |
| SED | 0.201 | ||
| ZHU | 0.142 | ||
| MCED1 | 0.2 | 0.173 | |
| MCED2 | 0.2 | 0.172 | |
| MCED1 | 0.4 | 0.324 | |
| MCED2 | 0.4 | 0.316 | |
| (0.5, 0, 0.5, 0.4) | NED | 0.462 | |
| SED | 0.673 | ||
| ZHU | 0.460 | ||
| MCED1 | 0.2 & 0.4 | 0.854 | |
| MCED2 | 0.2 & 0.4 | 0.853 | |
| (0.5, 0, 0.5, 0.6) | NED | 0.778 | |
| SED | 0.945 | ||
| ZHU | 0.807 | ||
| MCED1 | 0.2 & 0.4 | 0.994 | |
| MCED2 | 0.2 & 0.4 | 0.994 |
1
non-enrichment design
2
Simon and Simon’s enrichment design
3
Zhu’s adaptive design
4
CARA enrichment design using Wald test
5
CARA enrichment design using pseudo-randomization test