Table 2.
Demographics, Clinical, and Outcome Data of Patients with CRMO (n=80)
| Variables | Values |
|---|---|
| Demographics | |
| Sex, F:M (ratio) | 52:28 (1.86:1) |
| Mean age, years, mean ± SD (range) | 15.15 ± 4.57 (3.5 - 25.6) |
| Age at onset, years, mean ± SD (range) | 9.764 ± 3.66 (2.0 - 16.8) |
| Age at diagnosis, years, mean ± SD (range) | 10.28 ± 3.52 (2.0 - 16.9) |
| Follow-up, months, mean ± SD (range) | 37.13 ± 27.67 (1 - 117) |
| Delay in diagnosis, months, mean ± SD (range) | 6.21 ± 9.75 (0 - 50) |
| Ethnicity | |
| White | 46 (57.5%) |
| Hispanic | 15 (18.75%) |
| Black | 12 (15%) |
| Asian | 5 (6.25%) |
| Native American | 1 (1.25%) |
| Medical History of Autoimmune Disease | 8 (10%) |
| Family History of Autoimmune Disease | 37 (46%) |
| Dermatologic Symptoms | |
| Other | 12 (15%) |
| Psoriasis | 10 (12.5%) |
| Eczema | 6 (7.5%) |
| Palmoplantar pustulosis | 2 (2.5%) |
| Symptoms | |
| Antalgic gait | 36 (45%) |
| Local inflammation | 24 (30%) |
| Fever/Fatigue | 21 (26.25%) |
| Nocturnal pain | 11 (13.75%) |
| Arthritis | 7 (8.75%) |
| Clinical Course | |
| Clinical localizations per patient, median (IQR) | 1 (1 - 2) |
| Clinically unifocal | 46 (57.5%) |
| Recurrence | 43 (53.75%) |
| Time from diagnosis to first recurrence, months, median (IQR) | 13 (5 - 28) |
| Rheumatology Referral | |
| None | 2 (2.5%) |
| Before biopsy | 18 (22.5%) |
| After biopsy | 42 (52.5%) |
| Without biopsy | 18 (22.5%) |
| Remission | |
| Clinical remission⁎ | 36 (45%) |
| Length of symptoms, years, median (IQR) | 1.68 (0.72 - 3.05) |
| Subsequently diagnosed with additional condition | 6 (7.5%) |
⁎
Absence of pain/swelling, no biochemical inflammation, and no active lesions on MRI for >6 months. CRMO = chronic recurrent multifocal osteomyelitis; TNF = tumor necrosis factor; NSAID = nonsteroidal anti-inflammatory drug; MRI = Magnetic Resonance Imaging.