Figure 4.

Relationship between the betweenness and the closeness centrality for TEM1 beta-lactamase. For each amino acid of TEM1 beta-lactamase, we plot the betweenness versus the closeness centrality. We notice that the points are not approximately disposed along a "natural curve", which suggests that there is no natural "functional relationship" between these two centrality measurements. Therefore, we cannot deduce one centrality measurement from the other one. However, we notice that the cloud of points is located under the curve "y = 0.058x-0.09". This implies that the set of amino acids with the highest betwenness is included in a set of amino acids with highest closeness centrality (for a given cut-off).