Table 3.

Type of residues predicted by network and phylogenetic analyses

SITE	Closeness Centrality	HSSP	ConSeq
Metal binding	75	126	134
Metal binding in active site	52	24	38
Ligand binding	57	63	59
Active site	110	104	116

The number of predicted residues that were annotated as SITE in 128 selected proteins is reported for columns Closeness Centrality, HSSP and ConSeq. These last two columns correspond to the results obtained with phylogenetic methods (see Methods section). Four classes of SITE annotations were distinguished and included in column SITE.