Table 1.

Resistance to ionising irradiation and cytotoxic drugs in relation to the p53 codon 72 status

	all patients				p53 wild type
	p53 codon 72 Arg/Arg	p53 codon 72 Pro/Pro	p53 codon 72 Arg/Pro	p	p53 codon 72 Arg/Arg	p53 codon 72 Pro/Pro	p53 codon 72 Arg/Pro	p
γ-irradiation (% surviving cells)	36.3 ± 4.7 (n = 49)	50.0 ± 10.1 (n = 7)	24.2 ± 4.8 (n = 26)	0.099	30.6 ± 4.8 (n = 39)	54.7 ± 13.4 (n = 5)	22.9 ± 4.9 (n = 25)	0.14
log10 LC90 chlorambucil	0.73 ± 0.07 (n = 78)	0.76 ± 0.19 (n = 9)	0.62 ± 0.08 (n = 49)	0.63	0.6 ± 0.08 (n = 61)	0.76 ± 0.22 (n = 7)	0.57 ± 0.08 (n = 46)	0.70
log10 LC90 mafosfamide	0.32 ± 0.05 (n = 75)	0.37 ± 0.12 (n = 9)	0.21 ± 0.05 (n = 47)	0.39	0.3 ± 0.06 (n = 59)	0.38 ± 0.16 (n = 7)	0.21 ± 0.05 (n = 44)	0.42
log10 LC90 fludarabine	0.18 ± 0.08 (n = 78)	0.13 ± 0.18 (n = 9)	-0.32 ± 0.1 (n = 49)	0.32	0.11 ± 0.1 (n = 61)	0.22 ± 0.23 (n = 7)	-0.06 ± 0.01 (n = 46)	0.28
log10 LC90 cladribine	-0.76 ± 0.1 (n = 78)	-0.85 ± 0.18 (n = 9)	-1.0 ± 0.11 (n = 49)	0.10	-0.89 ± 0.1 (n = 61)	-0.79 ± 0.22 (n = 7)	-1.04 ± 0.11 (n = 46)	0.22
log10 LC90 vincristine	0.13 ± 0.1 (n = 55)	0.01 ± 0.27 (n = 8)	-0.22 ± 0.11 (n = 39)	0.71	-0.14 ± 0.11 (n = 40)	0.05 ± 0.33 (n = 6)	-0.25 ± 0.11 (n = 36)	0.59
log10 LC90 doxorubicin	-0.55 ± 0.04 (n = 78)	-0.52 ± 0.06 (n = 9)	-0.61 ± 0.05 (n = 49)	0.64	-0.55 ± 0.05 (n = 61)	-0.49 ± 0.07 (n = 7)	-0.63 ± 0.05 (n = 46)	0.35
log10 LC90 methylprednisolone	0.99 ± 0.14 (n = 78)	1.36 ± 0.45 (n = 9)	0.95 ± 0.18 (n = 48)	0.70	0.99 ± 0.16 (n = 61)	1.52 ± 0.47 (n = 7)	0.95 ± 0.18 (n = 45)	0.57

For the cytostatic drugs (chlorambucil, mafosfamide, fludarabine, cladribine, vincristine, doxorubicin or methylprednisolone) log₁₀ LC₉₀ concentrations were compared. In case of ionizing γ-irradiation with a fixed dose of 2 Gy, percentages of surviving cells were compared. p53 WT: wild type p53 gene. Mean +/- SEM is given. Statistical significance was calculated by means of the Kruskal-Wallis test.