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. 2025 May 19;15:17396. doi: 10.1038/s41598-025-86875-2

Table 3.

Linear regression analysis in crude and adjusted models investigating the association between hematological indices and major depressive disorder according to sex.

Variables Major depressive disorder
Crude model P-value Adjusted model 1 P-value Adjusted model 2 P-value
WBC Males −0.009(−0.255, 0.274) 0.946 −0.051(−0.319, 0.217) 0.71 −0.095(−0.036, 0.174) 0.489
Females 0.079(−0.03, 0.141) 0.483 −0.059(−0.257, 0.157) 0.593 −0.08(−0.30, 0.14) 0.425
RBC Males −0.05(−0.0121, 0.023) 0.179 −0.051(−0.123, 0.021) 0.166 −0.042(−0.114, 0.03) 0.251
Females −0.004(−0.056, 0.047) 0.88 0.005(−0.056, 0.047) 0.861 −0.007(0.059, −0.045) 0.792
HGB Males −0.07(−0.25, 0.11) 0.46 −0.07(−0.26, 0.11) 0.429 −0.07(−0.248, 0.115) 0.472
Females 0.02(0.15, −0.12) 0.80 0.023(−0.111, 0.157) 0.741 −0.005(−0.14, 0.13) 0.943
HCT Males −0.21(−0.69, 0.28) 0.40 −0.25(−0.73, 0.238) 0.318 −0.21(−0.69, 0.27) 0.399
Females 0.08(0.44, −0.28) 0.67 0.086(−0.273, 0.446) 0.637 0.015(−0.347, 0.378) 0.934
MCV Males 0.37(−0.46, 1.19) 0.38 0.32(−0.51, 1.15) 0.449 0.26(−0.58, 1.09) 0.543
Females 0.16(−0.58, 0.90) 0.67 0.186(−0.55, 0.92) 0.622 0.093(−0.065, 0.839) 0.807
MCH Males 0.13(−0.21, 0.48) 0.44 0.13(−0.21, 0.48) 0.446 0.102(−0.24, 0.45) 0.563
Females 0.03(−0.27, 0.33) 0.85 0.043(−0.255, 0.34) 0.778 0.006(−0.295, 0.306) 0.971
MCHC Males 0.02(0.12, 0.15) 0.78 0.04(−0.10, 0.17) 0.604 0.022(−0.114, 0.155) 0.754
Females −0.03(−0.13, 0.08) 0.61 −0.02(−0.12, 0.08) 0.688 −0.03(−0.13, 0.07) 0.572
RDW Males −0.09( −0.17, −0.003) 0.04 −0.10(−0.18, −0.12) 0.025 −0.1(−0.18, −0.01) 0.022
Females −0.04(−0.14, 0.06) 0.45 0.05(−0.15, 0.05) 0.34 −0.04(−0.14, 0.06) 0.462
PLT Males 0.73(−6.65, 8.12) 0.85 1.63(−5.76, 9.02) 0.665 2.04(−5.40, 9.48) 0.59
Females 2.57(−3.99, 9.13) 0.44 2.47(−4.05, 8.989) 0.458 2.42(−4.18, 9.02) 0.472
N/L(NLR) Males 0.10( 0.01, 0.19) 0.02 0.09(−0.002, 0.177) 0.046 0.097(0.009, 0.18) 0.031
Females −0.005(−0.07, 0.07) 0.90 −0.0002(−0.07, 0.07) 0.996 0.005(−0.065, 0.075) 0.895
N Males 0.12(−1.78, 2.02) 0.90 −0.35(−2.26, 1.56) 0.72 −0.19(−2.11, 1.73) 0.846
Females −0.21(−1.71, 1.29) 0.78 0.10(−1.58, 1.38) 0.894 −0.17(−1.5, 1.48) 0.982
L Males −0.19(−1.97, 1.58) 0.83 0.21(−1.57, 1.99) 0.815 0.037(−1.75, 1.83) 0.967
Females 0.14(−1.25, 1.54) 0.84 0.05(−1.33, 1.44) 0.941 −0.015(−1.42, 1.39) 0.984
M Males 0.015(−0.255, 0.285) 0.913 0.066(−0.205, 0.34) 0.632 0.08(−0.19, 0.35) 0.561
Females 0.088(−0.0177, 0.284) 0.38 0.07(−0.12, 0.27) 0.458 0.05(−0.14, 0.25) 0.605
MPV Males −0.01(0.08, −0.10) 0.79 −0.01(−0.1, 0.08) 0.824 −0.012(−0.11, 0.08) 0.804
Females −0.002(0.07, −0.08) 0.96 0.0005(−0.7, 0.7) 0.99 −0.003(−0.08, 0.07) 0.932
PCT Males 0.00002(−0.08, 0.006) 0.99 0.001(−0.005, 0.006) 0.787 0.001(−0.005, 0.007) 0.71
Females 0.002(−0.003, 0.007) 0.49 0.002(−0.003, 0.007) 0.501 0.002(−0.003, 0.007) 0.515
PDW Males −0.03(−0.15, 0.08) 0.60 −0.03(−0.15, 0.08) 0.578 −0.04(−0.15, 0.08) 0.552
Females −0.04(−0.13, 0.05) 0.39 −0.03(−0.12, 0.06) 0.493 −0.04(−0.13, 0.05) 0.424

The Crud model was not adjusted.

Model 1 included age, education, physical activity, body mass index (BMI), histories of arteritis rheumatoid, diabetes and hypertension. Adjusted model 2 included all variables in model 1 and additionally included smoking, alcohol consumption, opium use. Significant values are in bold.