Figure 2.

Between-group comparisons on main study outcomes at different timepoints based on central histological sections. (A) Total cell response score [sum of semiquantitative scores (range, 0–4) on polymorphonuclear cells, lymphocytes, plasma cells, macrophages, giant cells, necrosis, max 24 points]. (B) Total biomaterial response score [sum of semiquantitative scores (range, 0–4) on neovascularization, fibrosis, fatty infiltrate, max 12 points]. (C) Total histological response score (sum of cell and biomaterial response, max 36 points). (D) Healing score, according to Shafer criteria (scale 1–4). (E) Estimated macroscopic and (F) estimated microscopic biodegradation (scale 0–5). Statistical testing performed with Friedman’s test or Wilcoxon signed-rank test. *, P<0.05. a, adapted data; d, day; NHS-POx, N-hydroxysuccinimide ester functionalized poly(2)oxazolines; o, original data; w, week.