Table 1.
Mediation proportion of metabolites or BIPs in the causal pathways linking BIPs or metabolites to migraine and its subtypes
| Exposure | Mediator | Outcome | The Effect of Exposure on Outcome β 1(95% CI) |
The Effect of Mediator on Outcome β2 (95% CI) |
The Effect of Exposure on Mediator β3 (95% CI) |
Mediation effect | Mediated Proportion (%) |
|---|---|---|---|---|---|---|---|
| Thickness of the right superior parietal gyrus | Nucleotide(CSF) | Overall migraine |
−0.274 (−0.407 -−0.141) |
−0.148 (−0.282 -−0.013) |
0.099 (0.015–0.183) |
-0.015 | 5.328% |
| Nucleotide(CSF) | Thickness of the left superior parietal gyrus | Overall migraine |
−0.148 (−0.282 -−0.013) |
−0.206 (−0.338 -−0.075) |
0.141 (0.020–0.262) |
-0.029 | 19.691% |
| Volume of the left lateral occipital cortex | pyridoxal(CSF) | MA |
0.201 (0.010–0.393) |
−0.559 (−1.037 -−0.080) |
−0.041 (−0.080 -−0.002) |
0.023 | 11.444% |
| ISOVF in the right uncinate fasciculus | X-15,674 | MO |
0.223 (0.037–0.408) |
0.237 (0.011–0.463) |
0.097 (0.007–0.187) |
0.023 | 10.292% |
| lysine(CSF) | Cortical surface area of the left postcentral gyrus | MO |
−1.033 (−1.853 -−0.213) |
0.216 (0.046–0.386) |
−0.524 (−1.005 -−0.043) |
-0.113 | 10.960% |