Table 2.
Heterogeneity test, Pleiotropy test and MR-PRESSO test.
| Exposure | Cochran’s Q P value | egger_intercept | MR-PRESSO global test P value |
|---|---|---|---|
| LPS-NAFLD | .200 | 0.548 | .302 |
| LPS-Percent liver fat | .10 | 0.51 | .168 |
| LPS-Overweight | .175 | 0.636 | .387 |
| LPS-Obesity | .038 | 0.576 | .058 |
| LPS-Type 2 diabetes | .707 | 0.464 | .673 |
| LPS-Waist circumference | .047 | 0.783 | .078 |
| LPS-Hypertension | .00 | 0.1608361 | .022 |
| LPS-HDL-c levels | .387 | 0.306 | .493 |
| LPS-Triglyceride levels | .576 | 0.317 | .431 |
| LPS-Fasting blood glucose | .9569845 | 0.8969849 | .987 |
| LPS-Insulin resistance | .9746196 | 0.2985206 | .94 |
| LBP-NAFLD | .9087747 | 0.3668788 | .873 |
| LBP-Percent liver fat | .4626318 | 0.2126812 | .392 |
| LBP-Overweight | .87988 | 0.5661833 | .974 |
| LBP-Obesity | .8266659 | 0.3229417 | .904 |
| LBP-Type 2 diabetes | .08268243 | NA | NA |
| LBP-Waist circumference | 1.77E-09 | 0.4748781 | <.001 |
| LBP-Hypertension | .000830803 | 0.7266216 | .031 |
| LBP-HDL-c levels | .370 | 0.439 | .402 |
| LBP-Triglyceride levels | .000641233 | 0.2758084 | .065 |
| LBP-Fasting blood glucose | .7800669 | 0.900061 | .817 |
| LBP-Insulin resistance | .6633514 | 0.5850178 | .919 |
| NAFLD-LPS | .529 | 0.278 | .41 |
| Percent liver fat-LPS | .559 | 0.347 | .267 |
| Overweight-LPS | .556 | 0.201 | .642 |
| Obesity-LPS | .309 | 0.277 | .241 |
| Type 2 diabetes-LPS | .237 | 0.162 | .3 |
| Waist circumference-LPS | .965 | 0.958 | .848 |
| Hypertension-LPS | .088 | 0.058 | .174 |
| HDL-c levels-LPS | 1.505 × 10-6 | 0.173 | <.001 |
| Triglyceride levels-LPS | .009 | 0.329 | <.001 |
| Fasting blood glucose-LPS | .807 | 0.163 | .285 |
| Insulin resistance-LPS | .537 | 0.874 | .234 |
| NAFLD-LBP | .053 | 0.62 | .135 |
| Percent liver fat-LBP | .35 | 0.736 | .162 |
| Overweight-LBP | .231 | 0.971 | .559 |
| Obesity-LBP | .879 | 0.597 | .911 |
| Type 2 diabetes-LBP | .463 | 0.098 | .214 |
| Waist circumference-LBP | .104 | 0.016 | .117 |
| Hypertension-LBP | .016 | 0.686 | .021 |
| HDL-c levels-LBP | .618 | 0.784 | .787 |
| Triglyceride levels-LBP | .0013 | 0.52 | .002 |
| Fasting blood glucose-LBP | .012 | 0.119 | .285 |
| Insulin resistance-LBP | .005 | 0.817 | .016 |
HDL-c = high density lipoprotein cholesterol, LBP = lipopolysaccharide-binding protein, LPS = lipopolysaccharide, NAFLD = nonalcoholic fatty liver disease.