Palmoplantar pustulosis (PPP) is commonly considered as a subtype of psoriasis with crops of sterile pustules on the palms and soles.

The etiology of PPP remains unclear, and it is usually treated similarly to psoriasis vulgaris.

We present three biopsy-proven, recalcitrant cases of PPP successfully treated with topical 2% crisaborole cream.

All patients reported improved symptoms and had a decrease in their palmoplantar pustulosis area and severity index (PPPASI) after 4 weeks of topical crisaborole treatment.

Topical crisaborole may provide a safe and cost-effective treatment for patients with recalcitrant PPP.