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Schematic representation of p53/MDM2 axis regulation by ncRNA in uveal melanoma. p53 and MDM2 reciprocally control each other by a negative feed-back loop. The p53/MDM2 axis is regulated by several ncRNAs in uveal melanoma, that can interfere with the p53-driven biological effects such as cell proliferation, apoptosis, migration and invasion. Created with BioRender.
