Table 2.

Model description for the PRS models presented in the manuscript

Model Name	Model description
Aβ.PRS.full	PRS including SNPs with a p-value < pT
Aβ.PRS.no.APOE	PRS including SNPs with a p-value < pT and excluding SNPs in the APOE region (chr19:44.4–46.5 Mb)
Aβ.PRS.1	PRS calculated as a weighted sum of Aβ.PRS.no.APOE (including SNPs with a p-value < pT) and the number of APOE4 alleles
Aβ.PRS.2	PRS calculated as a weighted sum of Aβ.PRS.no.APOE (including SNPs with a p-value < pT), the number of APOE2 alleles, and the number of APOE4 alleles