Table 3.

PRS prediction accuracy for the Aβ PET case-control dataset using varying pT thresholds and APOE modeling methods

pT	Aβ.PRS.full		Aβ.PRS.no.APOE		Aβ.PRS.1 (APOE4)	Aβ.PRS.2 (APOE4 + APOE2)
	N SNPs	AUC	N SNPs	AUC	AUC	AUC
APOE4	1	0.687	–	–	–	–
APOE2 + APOE4	2	0.716	–	–	–	–
1.0 × 10− 6	14	0.624	9	0.565	0.714	0.732
1.0 × 10− 5	41	0.641	36	0.506	0.716	0.735
1.0 × 10− 4	182	0.603	176	0.539	0.722	0.740
0.001	1144	0.571	1137	0.529	0.716	0.740
0.01	9,744	0.563	9,719	0.538	0.686	0.715
0.1	88,065	0.610	87,971	0.609	0.740	0.759